Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans [0.03%]
土壤线虫Caenorhabditis elegans的三种惰性炸药成分2,4-二硝基甲苯、叠氮化钠和硝基三唑酮的比较毒基因组学
Ping Gong,Keri B Donohue,Anne M Mayo et al.
Ping Gong et al.
Background: Ecotoxicological studies on the insensitive munitions formulation IMX-101 and its components 2,4-dinitroanisole (DNAN), nitroguanidine (NQ) and nitrotriazolone (NTO) in various organisms showed that DNAN was t...
Comparative Study
BMC systems biology. 2018 Dec 14;12(Suppl 7):92. DOI:10.1186/s12918-018-0636-0 2018
Mary Qu Yang,Sherman M Weissman,William Yang et al.
Mary Qu Yang et al.
Background: Single-cell RNA sequencing (scRNA-seq) technology provides an effective way to study cell heterogeneity. However, due to the low capture efficiency and stochastic gene expression, scRNA-seq data often contains...
MICRAT: a novel algorithm for inferring gene regulatory networks using time series gene expression data [0.03%]
基于时间序列基因表达数据推理基因调控网络的新算法MICRAT
Bei Yang,Yaohui Xu,Andrew Maxwell et al.
Bei Yang et al.
Background: Reconstruction of gene regulatory networks (GRNs), also known as reverse engineering of GRNs, aims to infer the potential regulation relationships between genes. With the development of biotechnology, such as ...
Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer [0.03%]
增高的AURKA促进膀胱癌细胞增殖并预示不良预后
Mengjie Guo,Sicheng Lu,Hongming Huang et al.
Mengjie Guo et al.
Background: Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer developme...
The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell [0.03%]
Aβ25-35诱导的SH-SY5Y细胞源外泌体中miR-4487/6845-3p在阿尔茨海默病病理中发挥重要作用
Ling Hu,Rong Zhang,Qiong Yuan et al.
Ling Hu et al.
Background: Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesi...
A multiple kernel density clustering algorithm for incomplete datasets in bioinformatics [0.03%]
一种基于生物信息学不完整数据集的多核密度聚类算法
Longlong Liao,Kenli Li,Keqin Li et al.
Longlong Liao et al.
Background: While there are a large number of bioinformatics datasets for clustering, many of them are incomplete, i.e., missing attribute values in some data samples needed by clustering algorithms. A variety of clusteri...
Shuhao Sun,Fima Klebaner,Xinan Zhang et al.
Shuhao Sun et al.
Background: Cancer is one of the leading causes for the morbidity and mortality worldwide. Although substantial studies have been conducted theoretically and experimentally in recent years, it is still a challenge to expl...
Novel EM based ML Kalman estimation framework for superresolution of stochastic three-states microtubule signal [0.03%]
基于EM的ML卡尔曼估计超分辨率随机三态微管信号的新框架
Vineetha Menon,Shantia Yarahmadian,Vahid Rezania
Vineetha Menon
Background: Recent research has found that abnormal functioning of Microtubules (MTs) could be linked to fatal diseases such as Alzheimer's. Hence, there is an imminent need to understand the implications of MTs for disea...
Quantifying the relative importance of experimental data points in parameter estimation [0.03%]
参数估计中实验数据点相对重要性的量化方法研究
Jenny E Jeong,Peng Qiu
Jenny E Jeong
Background: Ordinary differential equations (ODEs) are often used to understand biological processes. Since ODE-based models usually contain many unknown parameters, parameter estimation is an important step toward deeper...
Inferring phenotypes from substance use via collaborative matrix completion [0.03%]
通过协作矩阵填充从物质使用推断表型
Jin Lu,Jiangwen Sun,Xinyu Wang et al.
Jin Lu et al.
Background: Although substance use disorders (SUDs) are heritable, few genetic risk factors for them have been identified, in part due to the small sample sizes of study populations. To address this limitation, researcher...