Computational drug repositioning using meta-path-based semantic network analysis [0.03%]
基于元路径的语义网络分析的计算药物再定位
Zhen Tian,Zhixia Teng,Shuang Cheng et al.
Zhen Tian et al.
Background: Drug repositioning is a promising and efficient way to discover new indications for existing drugs, which holds the great potential for precision medicine in the post-genomic era. Many network-based approaches...
Identification of active signaling pathways by integrating gene expression and protein interaction data [0.03%]
通过整合基因表达和蛋白质相互作用数据识别活跃的信号通路
Md Humayun Kabir,Ralph Patrick,Joshua W K Ho et al.
Md Humayun Kabir et al.
Background: Signaling pathways are the key biological mechanisms that transduce extracellular signals to affect transcription factor mediated gene regulation within cells. A number of computational methods have been devel...
Parameter estimation of qualitative biological regulatory networks on high performance computing hardware [0.03%]
基于高性能计算硬件的定性生物调控网络参数估计方法研究
Muhammad Tariq Saeed,Jamil Ahmad,Jan Baumbach et al.
Muhammad Tariq Saeed et al.
Background: Biological Regulatory Networks (BRNs) are responsible for developmental and maintenance related functions in organisms. These functions are implemented by the dynamics of BRNs and are sensitive to regulations ...
Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors [0.03%]
促血管生成因子活化MAPK信号途径的机制研究
Min Song,Stacey D Finley
Min Song
Background: Angiogenesis is important in physiological and pathological conditions, as blood vessels provide nutrients and oxygen needed for tissue growth and survival. Therefore, targeting angiogenesis is a prominent str...
Multiple transcription factors contribute to inter-chromosomal interaction in yeast [0.03%]
多个转录因子在酵母染色体间的相互作用中起作用
Yulin Dai,Chao Li,Guangsheng Pei et al.
Yulin Dai et al.
Background: Chromatin interactions medicated by genomic elements located throughout the genome play important roles in gene regulation and can be identified with the technologies such as high-throughput chromosome conform...
William T Choi,Mehmet Tosun,Hyun-Hwan Jeong et al.
William T Choi et al.
Background: The mammalian brain is organized into regions with specific biological functions and properties. These regions have distinct transcriptomes, but little is known whether they may also differ in their metabolome...
Identification of gene signatures from RNA-seq data using Pareto-optimal cluster algorithm [0.03%]
基于Pareto最优聚类算法的RNA测序数据基因标记识别方法
Saurav Mallik,Zhongming Zhao
Saurav Mallik
Background: Gene signatures are important to represent the molecular changes in the disease genomes or the cells in specific conditions, and have been often used to separate samples into different groups for better resear...
Circular RNA expression profiles during the differentiation of mouse neural stem cells [0.03%]
小鼠神经干细胞分化过程中 Circular RNA 表达谱分析
Qichang Yang,Jing Wu,Jian Zhao et al.
Qichang Yang et al.
Background: Circular RNAs (circRNAs) have recently been found to be expressed in human brain tissue, and many lines ofevidence indicate that circRNAs play regulatory roles in neurodevelopment. Proliferation and differenti...
scdNet: a computational tool for single-cell differential network analysis [0.03%]
scdNet：单细胞差异网络分析的计算工具
Yu-Chiao Chiu,Tzu-Hung Hsiao,Li-Ju Wang et al.
Yu-Chiao Chiu et al.
Background: Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of the tumor heterogeneity. However, the highly sparse data matrices generated by the technology have posed...
GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization [0.03%]
具有嵌入基因集节点的自编码器（GSAE）用于基因组功能表征
Hung-I Harry Chen,Yu-Chiao Chiu,Tinghe Zhang et al.
Hung-I Harry Chen et al.
Background: Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their ...