Use of genome-scale models to get new insights into the marine actinomycete genus Salinispora [0.03%]
利用基因组规模模型深入研究海洋放线菌属Salinispora的新见解
Carolina A Contador,Vida Rodríguez,Barbara A Andrews et al.
Carolina A Contador et al.
Background: There is little published regarding metabolism of Salinispora species. In continuation with efforts performed towards this goal, this study is focused on new insights into the metabolism of the three-identifie...
Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resection [0.03%]
基于模型的虚拟患者分析预测了控制肝切除术后肝脏再生动态模式的关键术前和术后因素
Babita K Verma,Pushpavanam Subramaniam,Rajanikanth Vadigepalli
Babita K Verma
Background: Liver has the unique ability to regenerate following injury, with a wide range of variability of the regenerative response across individuals. Existing computational models of the liver regeneration are largel...
An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning [0.03%]
notch信号通路的基于智能体的模型阐明了发育构型确定中的三个复杂度层级
Elaine R Reynolds,Ryan Himmelwright,Christopher Sanginiti et al.
Elaine R Reynolds et al.
Background: The Notch signaling pathway is involved in cell fate decision and developmental patterning in diverse organisms. A receptor molecule, Notch (N), and a ligand molecule (in this case Delta or Dl) are the central...
Multi-omics integration reveals molecular networks and regulators of psoriasis [0.03%]
多组学整合揭示银屑病分子网络和调控因子
Yuqi Zhao,Deepali Jhamb,Le Shu et al.
Yuqi Zhao et al.
Background: Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have bee...
Plasmodium vivax readiness to transmit: implication for malaria eradication [0.03%]
间日疟原虫传播潜能的分子标记及其在疟疾消除中的应用价值研究
Swamy Rakesh Adapa,Rachel A Taylor,Chengqi Wang et al.
Swamy Rakesh Adapa et al.
Background: The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. viva...
Lili Wu,Hongli Wang,Qi Ouyang
Lili Wu
Background: Cells use signaling protein networks to sense their environment and mediate specific responses. Information about environmental stress is usually encoded in the dynamics of the signaling molecules, and qualita...
SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework [0.03%]
改进的约束基于模型框架探究酵母脂质代谢的灵活性：SLIMEr
Benjamín J Sánchez,Feiran Li,Eduard J Kerkhoven et al.
Benjamín J Sánchez et al.
Background: A recurrent problem in genome-scale metabolic models (GEMs) is to correctly represent lipids as biomass requirements, due to the numerous of possible combinations of individual lipid species and the correspond...
Modelling overflow metabolism in Escherichia coli with flux balance analysis incorporating differential proteomic efficiencies of energy pathways [0.03%]
采用包含能量途径差异蛋白质效率的通量平衡分析模拟大肠杆菌的代谢外流现象
Hong Zeng,Aidong Yang
Hong Zeng
Background: The formation of acetate by fast-growing Escherichia coli (E. coli) is a commonly observed phenomenon, often referred to as overflow metabolism. Among various studies that have been carried over decades, a rec...
DynamicME: dynamic simulation and refinement of integrated models of metabolism and protein expression [0.03%]
动态代谢与蛋白质表达集成模型的仿真和精化：动态MEA
Laurence Yang,Ali Ebrahim,Colton J Lloyd et al.
Laurence Yang et al.
Background: Genome-scale models of metabolism and macromolecular expression (ME models) enable systems-level computation of proteome allocation coupled to metabolic phenotype. ...
Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone [0.03%]
用于识别糖尿病神经病变及吡格列酮所诱导的连接性变化的信号通路交叉干扰扰动网络模型
Guillermo de Anda-Jáuregui,Kai Guo,Brett A McGregor et al.
Guillermo de Anda-Jáuregui et al.
Background: Aggregation of high-throughput biological data using pathway-based approaches is useful to associate molecular results to functional features related to the studied phenomenon. Biological pathways communicate ...