Identification of Hürthle cell cancers: solving a clinical challenge with genomic sequencing and a trio of machine learning algorithms [0.03%]
揭秘Hurthle细胞癌：利用基因组测序和三种机器学习算法应对临床难题
Yangyang Hao,Quan-Yang Duh,Richard T Kloos et al.
Yangyang Hao et al.
Background: Identification of Hürthle cell cancers by non-operative fine-needle aspiration biopsy (FNAB) of thyroid nodules is challenging. Resultingly, non-cancerous Hürthle lesions were conventionally distinguished fr...
PMAMCA: prediction of microRNA-disease association utilizing a matrix completion approach [0.03%]
基于矩阵补全的微小核糖核酸-疾病关联预测方法PMAMCA
Jihwan Ha,Chihyun Park,Sanghyun Park
Jihwan Ha
Background: Numerous experimental results have indicated that microRNAs (miRNAs) play a vital role in biological processes, as well as outbreaks of diseases at the molecular level. Despite their important role in biologic...
How to schedule VEGF and PD-1 inhibitors in combination cancer therapy? [0.03%]
如何在联合癌症治疗中安排VEGF和PD-1抑制剂的使用？
Xiulan Lai,Avner Friedman
Xiulan Lai
Background: One of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may i...
Adaptive information processing of network modules to dynamic and spatial stimuli [0.03%]
网络模块对动态和静态刺激的自适应信息处理
J Krishnan,Ioannis Floros
J Krishnan
Background: Adaptation and homeostasis are basic features of information processing in cells and seen in a broad range of contexts. Much of the current understanding of adaptation in network modules/motifs is based on the...
Correction to: Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone [0.03%]
糖尿病性神经病变及吡格列酮诱导的连接变化的途径交叉干扰扰动网络模型的修正版
Guillermo de Anda-Jáuregui,Kai Guo,Brett A McGregor et al.
Guillermo de Anda-Jáuregui et al.
Published Erratum
BMC systems biology. 2019 Mar 13;13(1):31. DOI:10.1186/s12918-019-0707-x 2019
Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster [0.03%]
unpaired 1基因过表达对果蝇寿命的影响研究
Alexey Moskalev,Ekaterina Proshkina,Alex Zhavoronkov et al.
Alexey Moskalev et al.
Background: The JAK/STAT signaling pathway is involved in many aging-related cellular functions. However, effects of overexpression of genes controlling JAK/STAT signal transduction on longevity of model organisms have no...
Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology [0.03%]
基于微流体装置的Caco-2模型在肠道界面中的嵌入以实现系统生物学多器官模型
Dmitry Sakharov,Diana Maltseva,Evgeny Knyazev et al.
Dmitry Sakharov et al.
Background: A cancer cell line originating from human epithelial colorectal adenocarcinoma (Caco-2 cells) serves as a high capacity model for a preclinical screening of drugs. Recent need for incorporating barrier tissue ...
Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts [0.03%]
宇航员心率自主神经调节相关尿蛋白组变化
Lyudmila H Pastushkova,Vasily B Rusanov,Anna G Goncharova et al.
Lyudmila H Pastushkova et al.
Background: The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke v...
Yuriy L Orlov,Ralf Hofestädt,Ancha V Baranova
Yuriy L Orlov
LSM-W2: laser scanning microscopy worker for wheat leaf surface morphology [0.03%]
基于激光扫描显微镜的 wheat叶片表皮细胞形态测量系统LSM-W2
Ulyana S Zubairova,Pavel Yu Verman,Polina A Oshchepkova et al.
Ulyana S Zubairova et al.
Background: Microscopic images are widely used in plant biology as an essential source of information on morphometric characteristics of the cells and the topological characteristics of cellular tissue pattern due to mode...