SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks [0.03%]
SignaLink 2 - 具有多种调控网络的信号通路资源
Dávid Fazekas,Mihály Koltai,Dénes Türei et al.
Dávid Fazekas et al.
Background: Signaling networks in eukaryotes are made up of upstream and downstream subnetworks. The upstream subnetwork contains the intertwined network of signaling pathways, while the downstream regulatory part contain...
Dynamics of the quorum sensing switch: stochastic and non-stationary effects [0.03%]
群体感应开关的动力学：随机和非平稳效应
Marc Weber,Javier Buceta
Marc Weber
Background: A wide range of bacteria species are known to communicate through the so called quorum sensing (QS) mechanism by means of which they produce a small molecule that can freely diffuse in the environment and in t...
Disentangling function from topology to infer the network properties of disease genes [0.03%]
解开功能与拓扑以推断疾病基因的网络属性
Dario Ghersi,Mona Singh
Dario Ghersi
Background: The topological features of disease genes within interaction networks are the subject of intense study, as they shed light on common mechanisms of pathology and are useful for uncovering additional disease gen...
Comparative Study
BMC systems biology. 2013 Jan 16:7:5. DOI:10.1186/1752-0509-7-5 2013
EnRICH: Extraction and Ranking using Integration and Criteria Heuristics [0.03%]
基于集成和准则启发式的抽取与排序（EnRICH）算法
Xia Zhang,M Heather West Greenlee,Jeanne M Serb
Xia Zhang
Background: High throughput screening technologies enable biologists to generate candidate genes at a rate that, due to time and cost constraints, cannot be studied by experimental approaches in the laboratory. Thus, it h...
Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT [0.03%]
应力体激活的模拟强调了RsbR和RsbT之间的别构相互作用
Ulf W Liebal,Thomas Millat,Jon Marles-Wright et al.
Ulf W Liebal et al.
Background: The stressosome is a bacterial signalling complex that responds to environmental changes by initiating a protein partner switching cascade, which leads to the release of the alternative sigma factor, σB. Stre...
Max Hoffmann,Ulrich S Schwarz
Max Hoffmann
Background: Focal adhesions are integrin-based cell-matrix contacts that transduce and integrate mechanical and biochemical cues from the environment. They develop from smaller and more numerous focal complexes under the ...
Revealing functionally coherent subsets using a spectral clustering and an information integration approach [0.03%]
基于谱聚类和信息整合的方法揭示功能上一致的子集
Adam J Richards,John H Schwacke,Bärbel Rohrer et al.
Adam J Richards et al.
Background: Contemporary high-throughput analyses often produce lengthy lists of genes or proteins. It is desirable to divide the genes into functionally coherent subsets for further investigation, by integrating heteroge...
A strategy to study pathway cross-talks of cells under repetitive exposure to stimuli [0.03%]
重复刺激作用下研究细胞通路交叉反应的策略
Yan Fu,Xiaoshan Jiang,Hang Zhang et al.
Yan Fu et al.
Background: Cells are subject to fluctuating and multiple stimuli in their natural environment. The signaling pathways often crosstalk to each other and give rise to complex nonlinear dynamics. Specifically repetitive exp...
Module-based subnetwork alignments reveal novel transcriptional regulators in malaria parasite Plasmodium falciparum [0.03%]
基于模块的子网络对齐在疟原虫Plasmodium falciparum中揭示了新的转录调节因子
Hong Cai,Changjin Hong,Jianying Gu et al.
Hong Cai et al.
Background: Malaria causes over one million deaths annually, posing an enormous health and economic burden in endemic regions. The completion of genome sequencing of the causative agents, a group of parasites in the genus...
Detection of protein complexes from affinity purification/mass spectrometry data [0.03%]
基于亲和纯化质谱数据的蛋白质复合体识别算法研究
Bingjing Cai,Haiying Wang,Huiru Zheng et al.
Bingjing Cai et al.
Background: Recent advances in molecular biology have led to the accumulation of large amounts of data on protein-protein interaction networks in different species. An important challenge for the analysis of these data is...