The ketamine chameleon: history, pharmacology, and the contested value of experience [0.03%]
氯胺酮：历史、药理学及其经验价值的争议性
Danny Diep,Sara de la Salle,Julien Thibault Lévesque et al.
Danny Diep et al.
Introduction: Since its synthesis in 1962, ketamine has been widely used in diverse medical contexts, from anesthesia to treatment-resistant depression. However, interpretations of ketamine's subjective effects remain pol...
Person-centeredness in medication management with people living with dementia [0.03%]
以人为本的认知症患者用药管理
Mouna Sawan,Brendan Mccormack,Danijela Gnjidic
Mouna Sawan
Population pharmacokinetic modeling and exposure-response analysis of Anrikefon: insights and implications in clinical analgesia [0.03%]
安力农药代动力学及量效关系研究及其临床镇痛应用启示
Kun Wang,Meixia Chen,Fengyan Xu et al.
Kun Wang et al.
Background: Anrikefon (HSK21542), a potent and selective peripheral kappa opioid receptor (KOR) agonist developed by Haisco, effectively blocks pain and itch signals. ...
Efficacy and safety of triple hormone receptor agonist retatrutide for the management of obesity: a systematic review and meta-analysis [0.03%]
司美格鲁肽治疗肥胖症有效性和安全性的系统评价和meta分析
Jay Tewari,Khalid Ahmad Qidwai,Ajoy Tewari et al.
Jay Tewari et al.
Introduction: Retatrutide is a novel triple hormone receptor agonist which has shown great promise in tackling obesity in preliminary trials. We did this systematic review and meta-analysis to pool the results of all avai...
Optimal use, combinations, and sequencing of therapies in advanced prostate cancer [0.03%]
转移性前列腺癌治疗的优化使用、联合和序贯疗法
Clayton K Oakley,Benjamin A Teply
Clayton K Oakley
Closing the gaps in the access to quality-assured medicines for global health: The case for oxytocin for postpartum haemorrhage [0.03%]
改善全球卫生领域优质药品获取途径的缺口：产后出血用缩宫素的质量保证问题
C C Lee,Luther Gwaza,Karin Rombouts et al.
C C Lee et al.
Introduction: Access to quality-assured medicines remains unequal between high-income and low-income countries. To bridge this gap, product development and supply in low- and middle-income countries (LMICs) should follow ...
Analysis of serum concentrations of metoprolol and its metabolite α-hydroxymetoprolol in patients with heart failure with reduced ejection fraction: a pilot study in routine health care [0.03%]
心力衰竭射血分数降低患者美托洛尔及其代谢产物α-羟基美托洛尔的血药浓度分析：日常医疗保健中的初步研究
Ivana Kacirova,Marie Lazarova,Romana Urinovska et al.
Ivana Kacirova et al.
Background: The cardioselective β-1 receptor antagonist metoprolol is used to treat heart failure. It is metabolized in the liver, primarily by cytochrome 2D6. ...
FLOT vs CROSS in localized esophageal adenocarcinoma: what is the current best strategy? [0.03%]
局部食管腺癌中FLOT与CROSS方案何者更优？
Jane E Rogers,Michael Leung,Jaffer A Ajani
Jane E Rogers
Gene therapy in cardiology: pioneering a new era in medical ethics and patient care [0.03%]
心血管基因治疗：开创医学伦理和患者护理的新时代
Maria Sara Mauro,Davide Capodanno
Maria Sara Mauro
Heejo Keum,Elina V Zhivov,Alex G Ortega-Loayza
Heejo Keum
Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers with undermined borders. The management of PG is challenging due to the lack of standardized evi...