Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective [0.03%]
尼古丁电子烟在戒烟中的作用：临床药理学角度的探讨
Victoria Ameral,Mehmet Sofuoglu,Megan M Kelly
Victoria Ameral
Introduction: Smoking cessation improves quality of life and increases life expectancy by up to a decade. Though two-thirds of people who smoke report a desire to quit, less than a quarter plan to quit within the coming m...
Impact of COVID-19 pandemic on the prescribing pattern of oral anticoagulants in the English primary care setting: a population-based segmented interrupted time series analysis of over 53 million individuals [0.03%]
COVID-19大流行对英国初级保健环境中口服抗凝剂处方模式的影响：一项超过5300万人群的分段中断时间序列分析
Amanj Kurdi,Abdulaziz Albutti,Omeed Darweesh et al.
Amanj Kurdi et al.
Background: The COVID-19 pandemic disrupted healthcare delivery, impacting oral anticoagulants (OAC) prescribing due to increased thromboembolic risks, Vaccine-induced immune thrombotic thrombocytopenia, and guidelines fa...
Complications related to oral corticosteroid use in asthma patients: a retrospective cohort study [0.03%]
哮喘患者使用口服皮质类固醇的相关并发症：一项回顾性队列研究
Chih-Cheng Lai,Chao-Hsien Chen,Ya-Hui Wang et al.
Chih-Cheng Lai et al.
Background: Asthma patients requiring oral corticosteroids (OCS) are at increased risk of adverse effects. Research focusing on asthma patients adhering to guideline-directed therapy remains limited. This study evaluates ...
Efficacy and safety of dupilumab in chronic rhinosinusitis with nasal polyps: A systematic review and meta-analysis [0.03%]
Dupilumab在伴有鼻息肉的慢性鼻窦炎中的有效性和安全性：系统评价和荟萃分析
Linger Sim,Norasnieda Md Shukri,Najib Majdi Yaacob et al.
Linger Sim et al.
Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) primarily displays type 2 inflammation, characterized by the activation of interleukin (IL)-4, IL-5, and IL-13 in the pathway. The purpose of this study is t...
Can we optimize the use of renin-angiotensin-system inhibitors in patients with chronic kidney disease? [0.03%]
我们能否优化肾素血管紧张素系统抑制剂在慢性肾脏疾病患者中的应用？
Panagiotis I Georgianos,Christodoula Kourtidou,Konstantinos Leivaditis et al.
Panagiotis I Georgianos et al.
Therapeutic drug monitoring in acute lymphoblastic leukemia-a deep dive into pharmacokinetics, -dynamics, and -genetics of antileukemic drugs [0.03%]
急性淋巴细胞白血病中的治疗药物监控-深度探讨抗白血病药物的药代动力学、药效动力学和药理遗传学
Linea Natalie Toksvang,Leiah J Brigitha,Inge M van der Sluis et al.
Linea Natalie Toksvang et al.
Introduction: Therapeutic drug monitoring (TDM) is important to optimize drug exposure and minimize toxicity for the individual patient. Areas covered: ...
Optimizing meropenem therapy in critical infections: a review of pharmacokinetics/pharmacodynamics research and clinical practice [0.03%]
ritical感染中优化美罗培南治疗:药动学/药效学研究和临床实践的回顾分析
Jingli Liao,Chao Li,Lixia Li
Jingli Liao
Introduction: Meropenem is a first-line antibiotic used in the treatment of severe infections. However, patients with critical infections often exhibit a notably low pharmacokinetic/pharmacodynamic (PK/PD) compliance rate...
Effectiveness and safety of thiopurines in inflammatory bowel disease patients with NUDT15 polymorphism: a real-world retrospective study [0.03%]
NUDT15多态性炎症性肠病患者使用硫嘌呤类药物的有效性和安全性：真实世界回顾性研究
Abhirup Chatterjee,Prateek Bhatia,Saroj K Sinha et al.
Abhirup Chatterjee et al.
Background: Thiopurine S-methyltransferase (TPMT) and Nudix hydrolase (NUDT15) polymorphisms predispose to thiopurine-related leukopenia. Methods: ...
Pharmacokinetics after bariatric surgery: adverse effects and drug safety issues in bariatric patients [0.03%]
代谢手术后的药代动力学：代谢手术患者的不良影响及药物安全性问题
Daniel Porat,Arik Dahan
Daniel Porat
Introduction: Medication management after bariatric surgery is a major and complex challenge. The altered gastrointestinal anatomy/physiology post-surgery may impact oral drug absorption/pharmacokinetics, with potential c...
Revisiting the association between sodium-glucose cotransporter-2 inhibitors and the risk of neoplasm in patients with type 2 diabetes: new insights from an updated systematic review and meta-analysis of randomized controlled trials [0.03%]
从随机对照试验的最新系统评价和meta分析中重新评估钠葡萄糖共转运体2抑制剂与2型糖尿病患者患癌风险之间的关联：新观点
Yiran Wang,Zonglin Li,Chu Lin et al.
Yiran Wang et al.
Objective: To evaluate the association between sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and the risk of neoplasm in patients with Type 2 diabetes (T2D). ...