A pharmacological profile of triheptanoin for the treatment of long-chain fatty acid oxidation disorders [0.03%]
三庚精治疗长链脂肪酸氧化障碍的药理特征
Raelynn Forsyth,Jerry Vockley
Raelynn Forsyth
Introduction: Long-chain fatty acid oxidation disorders (LC-FAODs) are rare inherited metabolic defects that present across the lifespan with skeletal, cardiac, and hepatic complications due to deficiency of energy produc...
Anti-seizure medications in patients with renal failure undergoing dialysis: how to manage? [0.03%]
透析患者的抗癫痫药物管理怎么办？
Oreste Marsico,Angelo Pascarella,Roberta Cutellè et al.
Oreste Marsico et al.
Introduction: Managing epilepsy in patients with end-stage kidney disease presents unique challenges due to altered pharmacokinetics of anti-seizure medications (ASMs) and the effects of dialysis treatments. Dialysis can ...
Precision dosing of perampanel in pediatric patients receiving oxcarbazepine combination therapy: physiologically based pharmacokinetic modeling and simulation [0.03%]
基于生理的药代动力学模型和模拟精准给药：接受 Oxcarbazepine 合并治疗的 Perampanel 儿科患者案例研究
Si-Ting Liu,Cheng-Jie Ke,Jing Su et al.
Si-Ting Liu et al.
Background: The combination of oxcarbazepine (OXC) with perampanel (PER) considerably reduces the blood concentration of PER in children, decreasing the antiepileptic effect of PER. This study aimed to predict PER exposur...
Progress towards a personalized management of antidiabetic medications in the elderly with type 2 diabetes [0.03%]
迈向针对2型糖尿病老年人的个性化抗糖尿病药物管理的有效途径
A J Scheen
A J Scheen
Introduction: Older adults with type 2 diabetes mellitus (T2DM) are increasingly numerous worldwide and present particularly difficult therapeutic challenges, especially concerning the proper selection of antidiabetic med...
Early response is a strong predictor of the long-term response in psoriasis patients receiving risankizumab or guselkumab in the real-world: a retrospective analysis [0.03%]
早期应答是利塞珠单抗或古塞库玛布真实世界治疗银屑病长期疗效的强力预测因素：回顾性分析
Neslihan Akdogan,Ömer Kutay Mutlu,Erdem Karabulut et al.
Neslihan Akdogan et al.
Background: Recognizing early treatment indicators that forecast the long-term effectiveness of maintenance therapy in psoriasis (PsO) could support the optimization of personalized treatments. We aimed to evaluate whethe...
Clozapine for older adults with severe mental illness: a systematic review and expert recommendations for clinical practice [0.03%]
氯氮平在老年严重精神疾病患者中应用的系统综述及临床实践专家推荐意见
Hélène Verdoux,Alexis Lepetit,Jose de Leon
Hélène Verdoux
Introduction: We aimed to synthesize the information relevant for clinical practice on the initiation and adaptation of clozapine treatment in new and long-term older adult users with severe mental illness (SMI). ...
Serum concentrations of valsartan and sacubitrilat, the active metabolite of sacubitril, in patients with heart failure with reduced ejection fraction: results of a pilot cross-sectional study [0.03%]
沙库必曲和其活性代谢产物沙库必曲塔利以及缬沙坦在射血分数降低的心力衰竭患者中的血清浓度：一项初步横断面研究的结果
Marie Lazarova,Romana Urinovska,Ivana Kacirova et al.
Marie Lazarova et al.
Background: Sacubitril/valsartan is used to treat heart failure. It consists of sacubitril (its active metabolite, sacubitrilat, acts as a neprilysin inhibitor) and valsartan (an angiotensin II type 1 receptor blocker). ...
Management of polypharmacy through deprescribing in older patients: a review of the role of AI tools [0.03%]
人工智能工具在老年人减药降阶梯治疗中的作用：综述
Ahmad Z Al Meslamani
Ahmad Z Al Meslamani
Introduction: Deprescribing is crucial for improving patient safety since polypharmacy in older adults raises the likelihood of negative health outcomes. Artificial intelligence (AI) role in deprescribing has been rarely ...
Hormonal contraception, past, present and future part 1: the early path - facts, stories and controversies [0.03%]
避孕激素研究进展（一）：早期的道路——事实、故事与争议
Manuela Farris,Carlo Bastianelli,Marwan Habiba et al.
Manuela Farris et al.
Introduction: Marketing in the late 1950s of Combined Oral Contraceptives (COC), represented the achievement of centuries of research in reproductive endocrinology that included the isolation of the main steroids produced...
Hormonal contraception, past, present and future part 2: optimizing combined oral contraceptives to decrease risks for healthy women [0.03%]
避孕药的发展历程（二）：优化复方口服避孕药以降低健康女性的风险因素
Manuela Farris,Carlo Bastianelli,Marwan Habiba et al.
Manuela Farris et al.
Introduction: Pincus and his group's initial research on hormonal contraception focused on progesterone. However, the natural compound could not be utilized in clinical practice because of the high incidence of breakthrou...