The use of NHS databases to identify and manage pharmacotherapy in people with dementia and/or late-life mental disorders [0.03%]
英国国家医疗服务体系数据库在痴呆患者和/或老年精神障碍患者药物治疗的识别与管理中的应用
Harsharon Kaur Sondh,Christoph Mueller,Delia Bishara et al.
Harsharon Kaur Sondh et al.
Introduction: Older people with dementia and mental health disorders frequently have co-occurring acute and chronic conditions resulting in polypharmacy. However, these populations are under-represented in clinical trials...
Therapeutic drug monitoring of Janus kinase inhibitors for precision dosing: where do we stand ? [0.03%]
精准给药的Janus激酶抑制剂治疗药物监测现状如何？
Jérémie Tachet,Catia Marzolini,Laurent A Decosterd et al.
Jérémie Tachet et al.
Introduction: Janus kinase inhibitors (JAKIs) emerged as novel therapies for a wide range of autoimmune and myeloproliferative neoplasms. JAKIs have remarkable clinical effectiveness, but emerging safety concerns have spa...
Practical considerations and emerging approaches for the management of vasomotor and sexual symptoms in breast cancer patients on endocrine therapies [0.03%]
乳腺癌患者在接受内分泌治疗期间出现血管舒缩症状和性功能障碍的管理策略及新方法
Jessica Fuhrman,Jina Yun,Amy Indorf
Jessica Fuhrman
Introduction: Vasomotor symptoms (VMS) and decreased libido are common menopausal symptoms. Patients with breast cancer receiving endocrine therapy experience new or worsening menopausal symptoms. Pharmacologic therapy fo...
Comprehensive understanding of the treatment of insomnia with lemborexant [0.03%]
从整体角度了解嗜睡症的治疗药物lemborexant
Yuichi Inoue,Michinori Koebis
Yuichi Inoue
Introduction: Benzodiazepine derivatives and Z-drugs have traditionally been the cornerstone of pharmacological insomnia treatment. However, concerns regarding increased risks of falls, next-morning residual effects, dose...
The orexin system and alcohol use disorder: bridging the gap between preclinical and clinical research [0.03%]
垂体上腺素系统与酒精使用障碍：弥合临床前和临床研究之间的差距
William W Stoops,Catherine F Moore,Justin C Strickland
William W Stoops
Semaglutide for the treatment of MASH: reaching into the ESSENCE of cardio-metabolic health? [0.03%]
司美格鲁肽治疗代谢相关脂肪性肝病（MAFLD）：来自ESSENCE的启示？
Christos Mademlis,Dimitrios Patoulias,Theocharis Koufakis et al.
Christos Mademlis et al.
Metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis poses a significant clinical challenge, especially given its strong association with obesity and type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 receptor agonist...
Pharmacology considerations for managing pregnancy in women with systemic lupus erythematosus [0.03%]
系统性红斑狼疮女性患者的孕期管理药物注意事项
Mayalen Uthurriage,Estibaliz Lazaro,Christophe Richez et al.
Mayalen Uthurriage et al.
Introduction: Pregnancy in women with systemic lupus erythematosus presents significant clinical challenges due to heightened risks of complications for both mother and fetus. Therapeutic management must be carefully tail...
Genotype-guided pharmacotherapy: the challenges of integrating pharmacogenomic testing into routine healthcare with a focus on experiences at a single site [0.03%]
基于基因型的药物治疗：以单一机构的经验为例，整合药物基因组学检测进入常规医疗所面临的挑战
Larisa H Cavallari,Emily J Cicali,Madeline Norris et al.
Larisa H Cavallari et al.
Introduction: Pharmacogenetic (PGx) testing remains widely underutilized despite strong evidence of genetic contributions to drug response and the availability of guidelines for integrating results into prescribing decisi...
A systematic mapping review on the capability of large language models in drug-drug interaction analysis [0.03%]
大型语言模型在药物相互作用分析能力方面的系统映射审查
Himel Mondal,Ipsita Dash,Shaikat Mondal et al.
Himel Mondal et al.
Background: Drug-drug interaction (DDI) is a global health concern affecting patient safety and treatment outcomes. Large language models (LLMs), such as ChatGPT, offer accessible alternatives; however, their effectivenes...
Considerations for the treatment of older adults with chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞白血病老年患者治疗的考虑因素
Anna Puła,Tadeusz Robak
Anna Puła
Introduction: Chronic lymphocytic leukemia (CLL) primarily affects older adults, with a median age at diagnosis around 70 years. While targeted therapies have improved outcomes, treatment decisions in the elderly are comp...