Sulaiman Sultan,Shishir Murarka,Ahad Jahangir et al.
Sulaiman Sultan et al.
The off-label use of chelation therapy (disodium edetate or EDTA) for prevention of cardiovascular disease (CVD) is widespread, despite the lack of convincing evidence for efficacy or approval from the Food and Drug Administration. After th...
Pharmacological treatment of depression in geriatric chronic pain patients: a biopsychosocial approach integrating functional restoration [0.03%]
老年慢性疼痛患者的抑郁症药物治疗：一种整合功能康复的生物-心理-社会模式
Peter Polatin,Kelley Bevers,Robert J Gatchel
Peter Polatin
A recent literature review concluded that the comorbidity of chronic pain and depression in adults is approximately 50%-65%. Physical and cognitive declines, concurrent multiple health conditions, and complex medication regimens add to the ...
Pharmacological treatment options for cryopyrin-associated periodic syndromes [0.03%]
冷吡啶蛋白相关周期综合征的药理治疗选择
Emmanuelle C Landmann,Ulrich A Walker
Emmanuelle C Landmann
Cryopyrin-associated periodic syndromes (CAPS) are rare monogenic autoinflammatory diseases, comprising a spectrum of phenotypes of varying severity. CAPS are associated with gain-of-function mutations in the NLRP3 inflammasome, a multiprot...
Benjamin A Teply,Emmanuel S Antonarakis
Benjamin A Teply
Common recurrent genetic alterations have been identified in prostate cancer through comprehensive sequencing efforts, and the prevalence of mutations in DNA repair pathway genes in patients with advanced and metastatic disease approaches 2...
Steven Chavoustie,Michael Frost,Ole Snyder et al.
Steven Chavoustie et al.
Opioid use disorder is a chronic, relapsing disease that encompasses use of both prescription opioids and heroin and is associated with a high annual rate of overdose deaths. Medical treatment has proven more successful than placebo treatme...
Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future [0.03%]
心血管疾病Omega-3多不饱和脂肪酸的过去、现在和未来
Yasuhiro Watanabe,Ichiro Tatsuno
Yasuhiro Watanabe
Large-scale epidemiological studies on Greenlandic, Canadian and Alaskan Eskimos have examined the health benefits of omega-3 fatty acids consumed as part of the diet, and found statistically significant relative reduction in cardiovascular...
Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review [0.03%]
口服选择性前列腺素I2受体激动剂塞利舒帕治疗肺动脉高压的药理学研究进展
Jesús Honorato Pérez
Jesús Honorato Pérez
Pulmonary hypertension is defined by a mean pulmonary artery pressure ≥25 mm Hg at rest. Management of pulmonary arterial hypertension (PAH) includes specific drug therapy with calcium channel blockers in vasoreactive patients, or drugs ap...
Santhi Mantravadi,Alexis Ogdie,Walter K Kraft
Santhi Mantravadi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially. The clinical effi...
Steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected Chinese patients [0.03%]
富马酸替诺福韦二吡呋酯在中国人艾滋病患者中的稳态药代动力学研究
Xiaoli Du,Huijuan Kou,Qiang Fu et al.
Xiaoli Du et al.
Background: The pharmacokinetic (PK) profile of tenofovir disoproxil fumarate in Chinese adults infected with HIV is unknown. Methods: ...
Shannon Chang,Stephen Hanauer
Shannon Chang
As our medical armamentarium for IBD continues to expand, it is essential that clinicians understand both optimizing and sequencing of individual and combination therapeutic approaches with available medications. Areas covered: This review ...