Methenamine Hippurate in UTI management: a reemerging pharmacological strategy [0.03%]
甲氧苄氨嘧啶在尿路感染管理中的作用：一种重新兴起的药理学策略
Mehwash Nadeem,Hashim Hashim
Mehwash Nadeem
A systematic review and meta-analysis of users versus non-users: unveiling the influence of proton pump inhibitors on capecitabine efficacy in colorectal cancer [0.03%]
系统评价和meta分析：奥美拉唑使用者与非使用者的开普拓疗效差异及对结直肠癌患者预后的影响
Francisco Cezar Aquino de Moraes,Estella Aparecida de Laia,Vitor Kendi Tsuchiya Sano et al.
Francisco Cezar Aquino de Moraes et al.
Introduction: Colorectal cancer is the second leading cause of cancer-related deaths worldwide. The impact of proton pump inhibitors (PPIs) on patients taking capecitabine, an oral fluoropyrimidine, remains uncertain, des...
Targeting HIF-2α: the role of belzutifan in clear cell renal carcinoma management [0.03%]
靶向HIF-2α：Belzutifan在透明细胞肾癌治疗中的作用
Alejandro Valdés,Gonzalo Pizarro,Jaime González-Montero et al.
Alejandro Valdés et al.
Introduction: Belzutifan is a first-in-class hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor. It targets the von Hippel-Lindau protein (pVHL)-HIF-vascular endothelial growth factor (VEGF) pathway, which is crucial in...
Changing landscapes and increasing relevance of immunotherapy in localized MSI-H gastric adenocarcinoma [0.03%]
局部MSI-H胃腺癌的治疗格局变化和免疫治疗的重要性增加
Jane E Rogers,Jaffer A Ajani
Jane E Rogers
The search for blood biomarkers useful in treating atopic dermatitis patients [0.03%]
寻寻用于治疗特应性皮炎患者的血液生物标志物
Kenji Izuhara,Satoshi Nunomura,Takeshi Nakahara et al.
Kenji Izuhara et al.
Introduction: Atopic dermatitis (AD) is diagnosed based on clinical signs and symptoms as well as on a clinical course lacking distinct laboratory or histological features; however, the recent appearance of molecularly ta...
The need for inhaled phosphodiesterase inhibitors in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病中吸入型磷酸二酯酶抑制剂的需求
Mario Cazzola,Luigino Calzetta,Paola Rogliani et al.
Mario Cazzola et al.
Introduction: The therapeutic implications of phosphodiesterase (PDE) inhibitors have attracted interest because PDEs are regarded as an intracellular target to be exploited for therapeutic advancements in the treatment o...
Avacopan as an add-on therapy for ANCA-associated vasculitis: a pharmacological overview [0.03%]
阿瓦普利单抗治疗ANCA相关性血管炎的联合疗法：药理学概览
Vladimir Tesar,Jan Miroslav Hartinger,Zdenka Hruskova
Vladimir Tesar
Introduction: ANCA-associated vasculitis (AAV) is a rare, life-threatening disease which may result in serious pulmonary and kidney damage. Cyclophosphamide or rituximab and high-dose glucocorticoids significantly improve...
Risk of new onset diabetes mellitus with pitavastatin as compared to atorvastatin and rosuvastatin: a systematic review and meta-analysis [0.03%]
匹伐他汀与阿托伐他汀和罗苏伐他汀新发糖尿病风险的系统评价和meta分析
Harmanjit Singh,Sangambir Kaur,Parul Kaushal et al.
Harmanjit Singh et al.
Background: Statins are linked to the risk of new-onset diabetes mellitus (NODM). While atorvastatin and rosuvastatin are often associated with NODM, pitavastatin may carry a lower risk. This systematic review and meta-an...
Immune checkpoint inhibition of metastatic melanoma: achieving high efficacy in the face of high toxicity [0.03%]
转移性黑色素瘤的免疫检查点抑制：高毒性和高疗效共存
Joy Justice,Roma A Kankaria,Douglas B Johnson
Joy Justice
Introduction: Immune checkpoint inhibitors (ICIs) have advanced the treatment of metastatic melanoma by blocking immune system down-regulators enhancing T-cell-mediated anti-tumor responses. However, many ICIs induce immu...
A scoping review of the clinical utility of adverse drug reaction causality analysis tools for use in the hospital setting [0.03%]
住院环境中不良药物反应因果分析工具临床应用性的系统评价
Benjamin Deutscher,Keshia De Guzman,Adam La Caze et al.
Benjamin Deutscher et al.
Introduction: Identification and monitoring of adverse drug reactions (ADRs) and interventions to reduce ADRs are essential for patient safety in hospitals. Causality analysis (CA) is an approach that helps to determine a...