Yi Du,Li-Li Ren,Qing-Qing Jiang et al.
Yi Du et al.
Background: Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. P...
The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus [0.03%]
视网膜输入的缺失扰乱了胆碱能脑干在小鼠外侧膝状核的投射发育
Guela Sokhadze,Tania A Seabrook,William Guido
Guela Sokhadze
Background: The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensi...
Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1 [0.03%]
早期光受体顺式调控元件的鉴定、表征及与Onecut1的关系研究
Nathalie Jean-Charles,Diego F Buenaventura,Mark M Emerson
Nathalie Jean-Charles
Background: Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors o...
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe [0.03%]
notch信号的动态变化调节了果蝇视叶中的神经干细胞状态转变
Esteban G Contreras,Boris Egger,Katrina S Gold et al.
Esteban G Contreras et al.
Background: Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cell...
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish [0.03%]
不同FGFs在斑马鱼脊髓损伤后神经发生中的调控作用不同
Yona Goldshmit,Jean Kitty K Y Tang,Ashley L Siegel et al.
Yona Goldshmit et al.
Background: Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal co...
Anthony P Barrasso,Shang Wang,Xuefei Tong et al.
Anthony P Barrasso et al.
Background: Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluo...
DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring [0.03%]
视觉系统连接过程中DSCAM对突触前和突触后结构及功能的中心连接的不同调节作用
Rommel A Santos,Ariel J C Fuertes,Ginger Short et al.
Rommel A Santos et al.
Background: Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal circuits. Developing circuits rely on an array of molecular cues to shape arbor morphology, but the u...
Genomic analysis of transcriptional networks directing progression of cell states during MGE development [0.03%]
单细胞测序技术解析纹状体中脑发育过程中的基因表达调控网络
Magnus Sandberg,Leila Taher,Jianxin Hu et al.
Magnus Sandberg et al.
Background: Homeodomain (HD) transcription factor (TF) NKX2-1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the inducti...
Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies [0.03%]
同 sympathetics故事：自主神经系统的亚分区以及发育研究的影响
Uwe Ernsberger,Hermann Rohrer
Uwe Ernsberger
Remarkable progress in a range of biomedical disciplines has promoted the understanding of the cellular components of the autonomic nervous system and their differentiation during development to a critical level. Characterization of the gen...
Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation [0.03%]
包裹细胞在神经元分化早期利用动态平铺法进行发育和损伤修复
Ev L. Nichols,Lauren A Green,Cody J Smith
Ev L. Nichols
Background: Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathm...