The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology [0.03%]
轴突稳态模型-解释微管束在轴突维持和病理中的作用及调节机制
Ines Hahn,André Voelzmann,Yu-Ting Liew et al.
Ines Hahn et al.
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes the...
sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS [0.03%]
SLI对果蝇感觉神经元形态和迁移的维持是必需的
Madison Gonsior,Afshan Ismat
Madison Gonsior
Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to their proper final position. The la...
Commissural axon guidance in the developing spinal cord: from Cajal to the present day [0.03%]
从卡哈尔到现在的脊髓发育中的联合神经元轴突引导
J D Comer,S Alvarez,S J Butler et al.
J D Comer et al.
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners. Essential to this pr...
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development [0.03%]
视网膜固有感光神经节细胞的细胞属性在产后发育中的变化规律
Jasmine A Lucas,Tiffany M Schmidt
Jasmine A Lucas
Background: Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are als...
Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis [0.03%]
脊髓发育过程中神经干/前体细胞增殖能力丧失的理论分析研究
Manon Azaïs,Eric Agius,Stéphane Blanco et al.
Manon Azaïs et al.
In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of this process, from tissue-scale m...
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse [0.03%]
小脑形态发生稳态恢复下的.Car8突变体小鼠持续存在的运动障碍
Lauren N Miterko,Joshua J White,Tao Lin et al.
Lauren N Miterko et al.
Background: Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of h...
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain [0.03%]
斑马鱼prdm12b独立于nkx6.1抑制作用促进神经管p1区eng1b表达
Ozge Yildiz,Gerald B Downes,Charles G Sagerström
Ozge Yildiz
Background: Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral...
Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors [0.03%]
小脑原条谱系遗传清除后可通过侧脑室区衍生的祖细胞适应性重组进行补偿反应
Alexandre Wojcinski,Morgane Morabito,Andrew K Lawton et al.
Alexandre Wojcinski et al.
Background: The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependen...
TrkB expression and dependence divides gustatory neurons into three subpopulations [0.03%]
一种受体酪氨酸激酶的表达和依赖性将味觉神经元分为三个亚群
Jennifer Rios-Pilier,Robin F Krimm
Jennifer Rios-Pilier
Background: During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate ...
An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development [0.03%]
COE类型转录因子在轴索运动神经元发育中的古老作用
Catarina Catela,Edgar Correa,Kailong Wen et al.
Catarina Catela et al.
Background: Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun...