A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage [0.03%]
一个新的时间身份窗口在单一祖细胞系中生成交替的Eve+/Nkx6+运动神经元亚型
Austin Seroka,Rita M Yazejian,Sen-Lin Lai et al.
Austin Seroka et al.
Background: Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate "cardinal class...
Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes [0.03%]
特定功能通路的罕见变异与人类神经管缺陷多种亚表型的相关性研究
Jizhen Zou,Fang Wang,Xueyan Yang et al.
Jizhen Zou et al.
Background: Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to e...
The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance [0.03%]
阿贝林C末端四分之一结构域通过调控WAVE调节复合物和Enabled来指导轴突导向
Han Sian Joshua Cheong,Mark Nona,Samantha Barbara Guerra et al.
Han Sian Joshua Cheong et al.
Background: Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work...
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease [0.03%]
HUWE1泛素连接酶在神经系统发育、功能及疾病发生中的作用
Andrew C Giles,Brock Grill
Andrew C Giles
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 reg...
Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells [0.03%]
在命运限制的视网膜祖细胞中分析Onecut1表达的顺式调控元件
Sruti Patoori,Nathalie Jean-Charles,Ariana Gopal et al.
Sruti Patoori et al.
Background: The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-...
Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function [0.03%]
Enabled促进果蝇神经突触的形态建成及活性区的形成和功能调节
Elizabeth M McNeill,Cheryl Thompson,Brett Berke et al.
Elizabeth M McNeill et al.
Background: Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-ass...
Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life [0.03%]
Lrig1表达从前瞻性鉴定出室管膜-亚室管膜区干细胞并在整个成年期具有神经发生能力
Hyung-Song Nam,Mario R Capecchi
Hyung-Song Nam
Background: Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in culture...
An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells [0.03%]
一个可诱导型Cre小鼠品系：少量靶向神经系统细胞（包括雷马克施万细胞）
Darshan Sapkota,Joseph D Dougherty
Darshan Sapkota
Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround smaller axons and do not myelina...
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries [0.03%]
评估抗Nogo治疗脊髓损伤的有效性
Raihan Mohammed,Kaesi Opara,Rahul Lall et al.
Raihan Mohammed et al.
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and can be crippling to a person's he...
Fenge Li,Danye Jiang,Melanie A Samuel
Fenge Li
Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in part because such analysis is chal...