The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination [0.03%]
少突胶质细胞特异的孤儿G蛋白偶联受体Gpr62在中枢神经系统髓鞘形成中并非必需
Curtis M Hay,Stacey Jackson,Stanislaw Mitew et al.
Curtis M Hay et al.
Background: Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin in order to allow rapid electrical conduct...
Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification [0.03%]
转录因子Pou4f1/Brn3a和神经营养因子受体Ret在视网膜神经节细胞类型特化中的遗传相互作用
Vladimir Vladimirovich Muzyka,Tudor Constantin Badea
Vladimir Vladimirovich Muzyka
Background: While the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with neurotrophic signaling is largely unexplored. In mice, the transcription fact...
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons [0.03%]
神经元dystroglycan调节餐后发育时期的胆囊收缩素/大麻素受体-1间神经元
Daniel S Miller,Kevin M Wright
Daniel S Miller
Background: The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in th...
Rebecca Shi,Daniel A Kramer,Baoyu Chen et al.
Rebecca Shi et al.
Background: Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched de...
Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis [0.03%]
非洲爪蟾脊髓损伤再生和非再生阶段的细胞反应
Gabriela Edwards-Faret,Karina González-Pinto,Arantxa Cebrián-Silla et al.
Gabriela Edwards-Faret et al.
Background: The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading ...
The role of astrocyte-mediated plasticity in neural circuit development and function [0.03%]
星形胶质细胞介导的可塑性在神经环路发育和功能中的作用
Nelson A Perez-Catalan,Chris Q Doe,Sarah D Ackerman
Nelson A Perez-Catalan
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range from short-term modifications on ...
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex [0.03%]
nectin-3的精确水平对于产后视觉皮层正确突触形成是必需的
Johanna Tomorsky,Philip R L Parker,Chris Q Doe et al.
Johanna Tomorsky et al.
Background: Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell...
Individual neuronal subtypes control initial myelin sheath growth and stabilization [0.03%]
单个神经元亚型控制初始髓鞘生长和稳定化
Heather N Nelson,Anthony J Treichel,Erin N Eggum et al.
Heather N Nelson et al.
Background: In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axo...
Synapse development and maturation at the drosophila neuromuscular junction [0.03%]
果蝇神经肌肉接头处突触的发育与成熟
Vivian T Chou,Seth A Johnson,David Van Vactor
Vivian T Chou
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions between a presynaptic neuron and a po...
The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction [0.03%]
SLC36转运蛋白Pathetic在营养限制条件下对神经干细胞增殖和大脑生长是必需的
Shiyun Feng,Evanthia Zacharioudaki,Kat Millen et al.
Shiyun Feng et al.
Background: Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is prote...