Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription [0.03%]
神经营养因子/Trk受体信号通过C/EBPα、-β和NeuroD募集到即时早期基因启动子在神经元细胞中起作用，并需要C/EBPs来诱导即时早期基因转录
Anna Maria Calella,Claus Nerlov,Rodolphe G Lopez et al.
Anna Maria Calella et al.
Background: Extracellular signaling through receptors for neurotrophins mediates diverse neuronal functions, including survival, migration and differentiation in the central nervous system, but the transcriptional targets...
POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia [0.03%]
POU域因子Brn3a在脊神经和三叉神经感觉神经节中调控特异的和共同的基因表达程序
S Raisa Eng,Iain M Dykes,Jason Lanier et al.
S Raisa Eng et al.
Background: General somatic sensation is conveyed to the central nervous system at cranial levels by the trigeminal ganglion (TG), and at spinal levels by the dorsal root ganglia (DRG). Although these ganglia have similar...
Direct non-cell autonomous Pax6 activity regulates eye development in the zebrafish [0.03%]
直接非细胞自主的Pax6活性调节斑马鱼眼发育
Brigitte Lesaffre,Alain Joliot,Alain Prochiantz et al.
Brigitte Lesaffre et al.
Background: Modifications in Pax6 homeogene expression produce strong eye phenotypes. This suggested to us that eye development might be an appropriate model to verify if homeoprotein intercellular passage has important f...
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe [0.03%]
果蝇视觉皮层中的纺锤体定向及神经干细胞命运决定的调控
Boris Egger,Jason Q Boone,Naomi R Stevens et al.
Boris Egger et al.
Background: The choice of a stem cell to divide symmetrically or asymmetrically has profound consequences for development and disease. Unregulated symmetric division promotes tumor formation, whereas inappropriate asymmet...
Second-order projection from the posterior lateral line in the early zebrafish brain [0.03%]
早期斑马鱼大脑后侧线第二级投射神经元的发育特性研究
Ryann M Fame,Carole Brajon,Alain Ghysen
Ryann M Fame
Background: Mechanosensory information gathered by hair cells of the fish lateral-line system is collected by sensory neurons and sent to the ipsilateral hindbrain. The information is then conveyed to other brain structur...
The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons [0.03%]
无脊椎动物神经元中电学特性获得的调节因子 EVEN-SKIPPED 的作用研究
Edward C G Pym,Tony D Southall,Christopher J Mee et al.
Edward C G Pym et al.
Background: While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription...
Flavio R Zolessi,Lucia Poggi,Christopher J Wilkinson et al.
Flavio R Zolessi et al.
In the absence of external cues, neurons in vitro polarize by using intrinsic mechanisms. For example, cultured hippocampal neurons extend arbitrarily oriented neurites and then one of these, usually the one nearest the centrosome, begins t...