Axonin-1/TAG-1 is required for pathfinding of granule cell axons in the developing cerebellum [0.03%]
轴丝蛋白-1/突触糖蛋白X是发育小脑颗粒细胞轴突行进的必须因素
Thomas Baeriswyl,Esther T Stoeckli
Thomas Baeriswyl
Background: Neural development consists of a series of steps, including neurogenesis, patterning, cell migration, axon guidance, and finally, synaptogenesis. Because all these steps proceed in a constantly changing enviro...
Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo [0.03%]
轴突暂时性分子TAG-1和层粘连蛋白α1调节生长锥的动态行为及初始轴突方向
Marc A Wolman,Vinoth K Sittaramane,Jeffrey J Essner et al.
Marc A Wolman et al.
Background: How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood. We have taken advantage of the unique fea...
Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development [0.03%]
果蝇大脑发育中中间前体细胞对神经干细胞增殖的放大作用
Bruno C Bello,Natalya Izergina,Emmanuel Caussinus et al.
Bruno C Bello et al.
Background: In the mammalian brain, neural stem cells divide asymmetrically and often amplify the number of progeny they generate via symmetrically dividing intermediate progenitors. Here we investigate whether specific n...
Forcing neural progenitor cells to cycle is insufficient to alter cell-fate decision and timing of neuronal differentiation in the spinal cord [0.03%]
迫使神经祖细胞周期不足以改变脊髓中细胞命运决定和神经元分化的时机
Valérie Lobjois,Sophie Bel-Vialar,Françoise Trousse et al.
Valérie Lobjois et al.
Background: During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate. Two main factors will determi...
Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [0.03%]
轴突导向中的冗余与补偿：果蝇Ptp10D/Ptp4E受体酪氨酸磷酸酶亚家族的遗传分析
Mili Jeon,Huong Nguyen,Sami Bahri et al.
Mili Jeon et al.
Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination. Highly penetrant...
Eric M Morrow,C-M Amy Chen,Constance L Cepko
Eric M Morrow
Background: Retinal bipolar cells comprise a diverse group of neurons. Cone bipolar cells and rod bipolar cells are so named for their connections with cone and rod photoreceptors, respectively. Morphological criteria hav...
Semaphorin6A acts as a gate keeper between the central and the peripheral nervous system [0.03%]
semaphorin6A作为中枢神经系统和外周神经系统的“守门人”发挥作用
Olivier Mauti,Elena Domanitskaya,Irwin Andermatt et al.
Olivier Mauti et al.
Background: During spinal cord development, expression of chicken SEMAPHORIN6A (SEMA6A) is almost exclusively found in the boundary caps at the ventral motor axon exit point and at the dorsal root entry site. The boundary...
The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle [0.03%]
E3连接酶Skp2通过细胞周期非依赖性机制调控神经分化
Hector Boix-Perales,Ian Horan,Helen Wise et al.
Hector Boix-Perales et al.
Background: The SCFskp2 complex is an E3 ubiquitin ligase that is known to target a number of cell cycle regulators, including cyclin-dependent kinase inhibitors, for proteolysis. While its role in regulation of cell divi...
Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers [0.03%]
小脑发生：多细胞附着中心决定叶模式
Anamaria Sudarov,Alexandra L Joyner
Anamaria Sudarov
Background: The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of ...
Maria Flavia Guinazu,David Chambers,Andrew Lumsden et al.
Maria Flavia Guinazu et al.
Background: The developing vertebrate brain is patterned first by global signalling gradients that define crude anteroposterior and dorsoventral coordinates, and subsequently by local signalling centres (organisers) that ...