The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter [0.03%]
Alexandra Tallafuss,Judith S Eisen
Alexandra Tallafuss
Background: Expression of correct neurotransmitters is crucial for normal nervous system function. How neurotransmitter expression is regulated is not well-understood; however, previous studies provide evidence that both ...
Ugo Borello,Inma Cobos,Jason E Long et al.
Ugo Borello et al.
Background: Growth, differentiation and regional specification of telencephalic domains, such as the cerebral cortex, are regulated by the interplay of secreted proteins produced by patterning centers and signal transduct...
Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons [0.03%]
鉴定影响感觉外周神经元和运动中枢神经元发育的树突形态发生基因
Yimiao Ou,Barbara Chwalla,Matthias Landgraf et al.
Yimiao Ou et al.
Background: Developing neurons form dendritic trees with cell type-specific patterns of growth, branching and targeting. Dendrites of Drosophila peripheral sensory neurons have emerged as a premier genetic model, though t...
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1 [0.03%]
分泌型APP通过与β1整合素的相互作用调控全长APP在神经突生长中的功能
Tracy L Young-Pearse,Allen C Chen,Rui Chang et al.
Tracy L Young-Pearse et al.
Background: Beta-amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble, ectodomain cleavage product (APPs-alpha) have be...
Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors [0.03%]
通过颅神经运动神经元前体表达谱分析鉴定Phox2b调控基因
Patrick Pla,Marie-Rose Hirsch,Stéphane Le Crom et al.
Patrick Pla et al.
Background: Branchiomotor neurons comprise an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rh...
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP [0.03%]
HOPRO蛋白对成人海马和胶质母细胞瘤干细胞系存活的调控作用研究
Arianna De Toni,Marie Zbinden,Jonathan A Epstein et al.
Arianna De Toni et al.
Background: Homeodomain proteins play critical roles in shaping the development of the embryonic central nervous system in mammals. After birth, neurogenic activities are relegated to stem cell niches, which include the s...
UV laser mediated cell selective destruction by confocal microscopy [0.03%]
共聚焦显微镜介导的紫外激光选择性破坏细胞实验研究进展
Laurent Soustelle,Benoît Aigouy,Marie-Laure Asensio et al.
Laurent Soustelle et al.
Analysis of cell-cell interactions, cell function and cell lineages greatly benefits selective destruction techniques, which, at present, rely on dedicated, high energy, pulsed lasers and are limited to cells that are detectable by conventi...
The L1-type cell adhesion molecule Neuroglian is necessary for maintenance of sensory axon advance in the Drosophila embryo [0.03%]
神经胶质细胞粘附分子Neuroglian对果蝇胚胎感觉轴突延伸的维持是必需的
Veronica Martin,Eli Mrkusich,Martin C Steinel et al.
Veronica Martin et al.
Background: Cell adhesion molecules have long been implicated in the regulation of axon growth, but the precise cellular roles played by individual cell adhesion molecules and the molecular basis for their action are stil...
Isaac H Bianco,Matthias Carl,Claire Russell et al.
Isaac H Bianco et al.
Background: Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and the mechanisms by which they develop are poorly desc...
Developmental patterning of glutamatergic synapses onto retinal ganglion cells [0.03%]
视网膜神经节细胞上的谷氨酸能突触的发育模式
Josh L Morgan,Timm Schubert,Rachel O L Wong
Josh L Morgan
Background: Neurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attaine...