A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells [0.03%]
Rho和Rho联结激酶信号在神经嵴细胞层分离中的负调节作用
Maya Groysman,Irit Shoval,Chaya Kalcheim
Maya Groysman
Background: Neural crest progenitors arise as epithelial cells and then undergo a process of epithelial to mesenchymal transition that precedes the generation of cellular motility and subsequent migration. We aim at under...
Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth [0.03%]
Fak56位于整合素alphaPS3betanu的下游并通过抑制MAPK激活来抑制神经肌肉接头生长
Pei-I Tsai,Hsiu-Hua Kao,Caroline Grabbe et al.
Pei-I Tsai et al.
Background: Focal adhesion kinase (FAK) functions in cell migration and signaling through activation of the mitogen-activated protein kinase (MAPK) signaling cascade. Neuronal function of FAK has been suggested to control...
Loss of transforming growth factor-beta 2 leads to impairment of central synapse function [0.03%]
转化生长因子β2缺乏导致中枢突触功能障碍
Katharina Heupel,Vardanush Sargsyan,Jaap J Plomp et al.
Katharina Heupel et al.
Background: The formation of functional synapses is a crucial event in neuronal network formation, and with regard to regulation of breathing it is essential for life. Members of the transforming growth factor-beta (TGF-b...
A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction [0.03%]
神经肌肉突触尼迪金的发育调节及尼迪金-2的作用
Michael A Fox,Matthew S P Ho,Neil Smyth et al.
Michael A Fox et al.
Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by...
A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation [0.03%]
一种化学遗传学策略揭示了SAD-1激酶在神经极化和突触形成过程中的不同时间需求
Joanne S M Kim,Brendan N Lilley,Chao Zhang et al.
Joanne S M Kim et al.
Background: Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation. In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is e...
Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons [0.03%]
在培养的嗅觉感觉神经元中表达外源功能性气味受体
Huaiyang Chen,Sepehr Dadsetan,Alla F Fomina et al.
Huaiyang Chen et al.
Background: Olfactory discrimination depends on the large numbers of odorant receptor genes and differential ligand-receptor signaling among neurons expressing different receptors. In this study, we describe an in vitro s...
Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling [0.03%]
皮层脊髓束轴突在(py_)处的转向需要plexin信号转导
Regina L Faulkner,Lawrence K Low,Xiao-Bo Liu et al.
Regina L Faulkner et al.
Background: The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at va...
Ken-ichi Inoue,Takashi Shiga,Yoshiaki Ito
Ken-ichi Inoue
Runt-related (Runx) transcription factors control diverse aspects of embryonic development and are responsible for the pathogenesis of many human diseases. In recent years, the functions of this transcription factor family in the nervous sy...
The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate [0.03%]
Sfrp1的Netrin结构域与Wnts相互作用并拮抗其在头神经板中的活性
Javier Lopez-Rios,Pilar Esteve,Jose Maria Ruiz et al.
Javier Lopez-Rios et al.
Background: Secreted frizzled related proteins (SFRPs) are multifunctional modulators of Wnt and BMP (Bone Morphogenetic Protein) signalling necessary for the development of most organs and the homeostasis of different ad...
The abdomen of Drosophila: does planar cell polarity orient the neurons of mechanosensory bristles? [0.03%]
Caroline C G Fabre,José Casal,Peter A Lawrence
Caroline C G Fabre
Background: In the adult abdomen of Drosophila, the shafts of mechanosensory bristles point consistently from anterior to posterior. This is an example of planar cell polarity (PCP); some genes responsible for PCP have be...