Heterogeneity in the developmental potential of motor neuron progenitors revealed by clonal analysis of single cells in vitro [0.03%]
单细胞体外克隆分析揭示运动神经元祖细胞的发育潜能异质性
Dritan Agalliu,Ira Schieren
Dritan Agalliu
Background: The differentiation of neural progenitors into distinct classes within the central nervous system occurs over an extended period during which cells become progressively restricted in their fates. In the develo...
Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [0.03%]
非洲爪蟾NM23-X4通过与p27Xic1相互作用调节视网膜星形胶质细胞生成
Toshiaki Mochizuki,Aikaterini Bilitou,Caroline T Waters et al.
Toshiaki Mochizuki et al.
Background: In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner. This activity is essenti...
Linda M Nevin,Michael R Taylor,Herwig Baier
Linda M Nevin
Background: Neuronal connections are often arranged in layers, which are divided into sublaminae harboring synapses with similar response properties. It is still debated how fine-grained synaptic layering is established d...
Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes [0.03%]
神经管衍生的Wnt信号与FGF信号协作形成并分化三叉神经板层
Claire A Canning,Lily Lee,Sarah Xinwei Luo et al.
Claire A Canning et al.
Background: Neurogenic placodes are focal thickenings of the embryonic ectoderm that form in the vertebrate head. It is within these structures that the precursors of the majority of the sensory neurons of the cranial gan...
Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points [0.03%]
semaphorin-6a控制多个决策点的皮质脊髓束轴突导向
Annette E Rünker,Graham E Little,Fumikazu Suto et al.
Annette E Rünker et al.
Background: The trajectory of corticospinal tract (CST) axons from cortex to spinal cord involves a succession of choice points, each of which is controlled by multiple guidance molecules. To assess the involvement of tra...
Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene [0.03%]
空斑基因决定的来源于同一神经前体细胞谱系的果蝇嗅觉中间神经元和投射神经元
Abhijit Das,Sonia Sen,Robert Lichtneckert et al.
Abhijit Das et al.
Background: Encoding of olfactory information in insects occurs in the antennal lobe where the olfactory receptor neurons interact with projection neurons and local interneurons in a complex sensory processing circuitry. ...
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation [0.03%]
Wnt通过经典和非经典信号通路在海马区突触形成中发挥相反作用
Elizabeth K Davis,Yimin Zou,Anirvan Ghosh
Elizabeth K Davis
Background: Wnt proteins comprise a large class of signaling molecules that regulate a variety of developmental processes, including synapse formation. Previous studies have shown Wnts to be involved in both the induction...
Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development [0.03%]
基因谱系追踪定义了背侧端脑放射状胶质细胞发育的不同神经发生和星形胶质细胞发生阶段
Todd E Anthony,Nathaniel Heintz
Todd E Anthony
Background: Radial glia comprise a molecularly defined neural progenitor population but their role in neurogenesis has remained contested due to the lack of a single universally accepted genetic tool for tracing their pro...
Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing [0.03%]
Robo蛋白在齿状纤维中间穿越中的关键作用及其在中间穿越后不被上调表达
Atsushi Tamada,Tatsuro Kumada,Yan Zhu et al.
Atsushi Tamada et al.
Background: Robo1, Robo2 and Rig-1 (Robo3), members of the Robo protein family, are candidate receptors for the chemorepellents Slit and are known to play a crucial role in commissural axon guidance in the spinal cord. Ho...
Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development [0.03%]
BMP-4在鸡胚肾上腺皮质细胞中的持续表达及其在嗜铬细胞发育中的作用
Katrin Huber,Aylin Franke,Barbara Brühl et al.
Katrin Huber et al.
Background: Adrenal chromaffin cells and sympathetic neurons both originate from the neural crest, yet signals that trigger chromaffin development remain elusive. Bone morphogenetic proteins (BMPs) emanating from the dors...