Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal [0.03%]
斑马鱼gbx1基因精炼梅克尔-延髓边界并介导Wnt8向后传递信号
Muriel Rhinn,Klaus Lun,Reiner Ahrendt et al.
Muriel Rhinn et al.
Background: Studies in mouse, Xenopus and chicken have shown that Otx2 and Gbx2 expression domains are fundamental for positioning the midbrain-hindbrain boundary (MHB) organizer. Of the two zebrafish gbx genes, gbx1 is a...
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression [0.03%]
P75NTR表达上调通过抑制Erk1/2诱导 engrailed缺陷的中脑多巴胺能神经元死亡
Kambiz N Alavian,Paola Sgadò,Lavinia Alberi et al.
Kambiz N Alavian et al.
Background: The homeodomain transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic (mesDA) neurons in a cell-autonomous and gene-dose-dependent manner. Homozygote mut...
Clifford B Saper,John H R Maunsell
Clifford B Saper
As the Neuroscience Peer Review Consortium (NPRC) ends its first year, it is worth looking back to see how the experiment has worked. In order to encourage dissemination of the details outlined in this Editorial, it will also be published i...
Cell proliferation in the Drosophila adult brain revealed by clonal analysis and bromodeoxyuridine labelling [0.03%]
溴脱氧尿苷和克隆分析揭示果蝇成虫脑中的细胞增殖现象
Jakob W von Trotha,Boris Egger,Andrea H Brand
Jakob W von Trotha
Background: The production of new neurons during adulthood and their subsequent integration into a mature central nervous system have been shown to occur in all vertebrate species examined to date. However, the situation ...
Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development [0.03%]
视黄酸调控非洲爪蟾轴突的细胞质多聚腺苷酸化及依赖于多聚腺苷酸化的mrna翻译
Andrew C Lin,Chin Lik Tan,Chien-Ling Lin et al.
Andrew C Lin et al.
Background: Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translati...
Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases [0.03%]
WNt信号活性引导面鳃神经元迁移，并涉及PCP通路以及JNK和ROCK激酶
Valérie Vivancos,Ping Chen,Nathalie Spassky et al.
Valérie Vivancos et al.
Background: Wnt proteins play roles in many biological processes, including axon guidance and cell migration. In the mammalian hindbrain, facial branchiomotor (FBM) neurons undergo a striking rostral to caudal migration, ...
Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain [0.03%]
菱形芽胚特异性的分析揭示了发育中后脑表达的遗传线索范围
David Chambers,Leigh Jane Wilson,Fabienne Alfonsi et al.
David Chambers et al.
Background: The Hox family of homeodomain transcription factors comprises pivotal regulators of cell specification and identity during animal development. However, despite their well-defined roles in the establishment of ...
Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon [0.03%]
Gsx基因是胚胎小鼠端脑中Ascl1的必要下游效应物
Bei Wang,Ronald R Waclaw,Zegary J Allen nd et al.
Bei Wang et al.
Background: The homeobox gene Gsx2 (formerly Gsh2) is known to regulate patterning in the lateral ganglionic eminence (LGE) of the embryonic telencephalon. In its absence, the closely related gene Gsx1 (previously known a...
Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex [0.03%]
FGF受体3的激活促进顶枕皮层的选择性生长和扩张
Rachel E Thomson,Peter C Kind,Nicholas A Graham et al.
Rachel E Thomson et al.
Background: Fibroblast growth factors (Fgfs) are important regulators of cerebral cortex development. Fgf2, Fgf8 and Fgf17 promote growth and specification of rostromedial (frontoparietal) cortical areas. Recently, the fu...
Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex [0.03%]
腺瘤性结肠息肉病蛋白COLI对于发育中的大脑皮质的正常生长和分化早期事件是必需的
Uladzislau Ivaniutsin,Yijing Chen,John O Mason et al.
Uladzislau Ivaniutsin et al.
Background: Adenomatous polyposis coli (Apc) is a large multifunctional protein known to be important for Wnt/beta-catenin signalling, cytoskeletal dynamics, and cell polarity. In the developing cerebral cortex, Apc is ex...