Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish [0.03%]
神经突触融合蛋白NSF突变斑马鱼中神经内分泌转录程序的动态调节
Deborah M Kurrasch,Linda M Nevin,Jinny S Wong et al.
Deborah M Kurrasch et al.
Background: Regulated secretion of specialized neuropeptides in the vertebrate neuroendocrine system is critical for ensuring physiological homeostasis. Expression of these cell-specific peptide markers in the differentia...
Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1 [0.03%]
Lhx9和Lhx1通过转录控制背侧间神经元的轴突导向和分选
Oshri Avraham,Yoav Hadas,Lilach Vald et al.
Oshri Avraham et al.
Background: Lim-HD proteins control crucial aspects of neuronal differentiation, including subtype identity and axonal guidance. The Lim-HD proteins Lhx2/9 and Lhx1/5 are expressed in the dorsal spinal interneuron populat...
Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons [0.03%]
参与斑马鱼胚胎神经元非基因组型甲状腺激素信号转导的分子成分
Marc A Yonkers,Angeles B Ribera
Marc A Yonkers
Background: Neurodevelopment requires thyroid hormone, yet the mechanisms and targets of thyroid hormone action during embryonic stages remain ill-defined. We previously showed that the thyroid hormone thyroxine (T4) rapi...
Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice [0.03%]
Pax6基因在胚胎小鼠背侧前脑的正常表达对其感觉丘脑皮层轴突发育至关重要
T Ian Simpson,Thomas Pratt,John O Mason et al.
T Ian Simpson et al.
Background: In addition to its well-known expression in dorsal telencephalic progenitor cells, where it regulates cell proliferation and identity, the transcription factor Pax6 is expressed in some ventral telencephalic c...
Timothy P O&#x;Connor,Katie Cockburn,Wenyan Wang et al.
Timothy P O&#x;Connor et al.
Background: Semaphorins are known to play an important role in axon guidance and growth by triggering dynamic rearrangements of the actin cytoskeleton in the neuronal growth cone. Intriguingly, some of these guidance mole...
Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis [0.03%]
神经粘附分子神经突触素NLGN1通过不同的机制在突触发生过程中募集PSD-95和NMDAR蛋白
Stephanie L Barrow,John Rl Constable,Eliana Clark et al.
Stephanie L Barrow et al.
Background: The cell adhesion molecule pair neuroligin1 (Nlg1) and beta-neurexin (beta-NRX) is a powerful inducer of postsynaptic differentiation of glutamatergic synapses in vitro. Because Nlg1 induces accumulation of tw...
Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system [0.03%]
介导秀丽隐杆线虫运动神经系统电突触特异性的连接蛋白UNC-7和UNC-9的相互作用
Todd A Starich,Ji Xu,I Martha Skerrett et al.
Todd A Starich et al.
Background: Approximately 10% of Caenorhabditis elegans nervous system synapses are electrical, that is, gap junctions composed of innexins. The locomotory nervous system consists of several pairs of interneurons and thre...
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells [0.03%]
Cyclin D1调节胚胎视网膜祖细胞的神经发生输出
Gaurav Das,Yoon Choi,Piotr Sicinski et al.
Gaurav Das et al.
Background: Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina. The cell cycle regulator cyclin D1 is expressed in ...
Vsx2 in the zebrafish retina: restricted lineages through derepression [0.03%]
斑马鱼视网膜中的Vsx2：通过去抑制产生限制性谱系
Marta Vitorino,Patricia R Jusuf,Daniel Maurus et al.
Marta Vitorino et al.
Background: The neurons in the vertebrate retina arise from multipotent retinal progenitor cells (RPCs). It is not clear, however, which progenitors are multipotent or why they are multipotent. ...
IgCAMs redundantly control axon navigation in Caenorhabditis elegans [0.03%]
IgCAMs 在冗余控制秀丽隐杆线虫轴突导航中的作用
Valentin Schwarz,Jie Pan,Susanne Voltmer-Irsch et al.
Valentin Schwarz et al.
Background: Cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) form one of the largest and most diverse families of adhesion molecules and receptors in the nervous system. Many members of this family media...