Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors [0.03%]
动态表达的Pax6影响视网膜祖细胞的命运决定和增殖
Yi-Wen Hsieh,Xian-Jie Yang
Yi-Wen Hsieh
Background: The paired homeobox protein Pax6 is essential for proliferation and pluripotency of retinal progenitors. However, temporal changes in Pax6 protein expression associated with the generation of various retinal n...
The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding [0.03%]
龟类基因编码参与轴突生长的导向分子免疫球蛋白基因
Bader Al-Anzi,Robert J Wyman
Bader Al-Anzi
Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules ...
Single cell cultures of Drosophila neuroectodermal and mesectodermal central nervous system progenitors reveal different degrees of developmental autonomy [0.03%]
果蝇神经外胚层和中胚层中枢神经系统前体单细胞培养揭示了不同程度的发育自主性
Karin Lüer,Gerhard M Technau
Karin Lüer
Background: The Drosophila embryonic central nervous system (CNS) develops from two sets of progenitor cells, neuroblasts and ventral midline progenitors, which behave differently in many respects. Neuroblasts derive from...
Robert Gasperini,Derek Choi-Lundberg,Michael J W Thompson et al.
Robert Gasperini et al.
Background: Homer proteins are post-synaptic density proteins with known functions in receptor trafficking and calcium homeostasis. While they are key mediators of synaptic plasticity, they are also known to function in a...
Mathematical modeling supports substantial mouse neural progenitor cell death [0.03%]
数学建模支持了大量小鼠神经祖细胞死亡的观点
Michael J McConnell,Hugh R MacMillan,Jerold Chun
Michael J McConnell
Background: Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data. Results: ...
Chick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neurons [0.03%]
一个新的Hoxb1和Shh下游效应物Chick Lrrn2在rhombomere 4运动神经元的选择性定位中的作用
Laura C Andreae,Andrew Lumsden,Jonathan D Gilthorpe
Laura C Andreae
Background: Capricious is a Drosophila adhesion molecule that regulates specific targeting of a subset of motor neurons to their muscle target. We set out to identify whether one of its vertebrate homologues, Lrrn2, might...
Dendrites differ from axons in patterns of microtubule stability and polymerization during development [0.03%]
发育期间微管稳定性和聚合模式的不同导致树突与轴突的区别
Katherine M Kollins,Robert L Bell,Matthew Butts et al.
Katherine M Kollins et al.
Background: Dendrites differ from axons in patterns of growth and development, as well as in morphology. Given that microtubules are key structural elements in cells, we assessed patterns of microtubule stability and poly...
Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections [0.03%]
视网膜皮层波不可能指导眼特异性视网膜-丘脑投射的形成
Leo M Chalupa
Leo M Chalupa
In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of ne...
Andrew Lumsden,Bill Harris,Joshua R Sanes et al.
Andrew Lumsden et al.
Retinal waves are likely to instruct the formation of eye-specific retinogeniculate projections [0.03%]
视网膜皮层波有可能指导眼特异性视网膜-丘脑投射的形成
Marla B Feller
Marla B Feller
Prior to eye-opening and the development of visual responses, the retina exhibits highly correlated spontaneous firing pattens termed retinal waves. Disruption of the normal spontaneous firing pattern either genetically or pharmacologically...