Cortico-cerebral histogenesis in the opossum Monodelphis domestica: generation of a hexalaminar neocortex in the absence of a basal proliferative compartment [0.03%]
无基底增殖区的六层新皮质发生——负鼠(Monodelphis domestica)脑发育案例研究
Elisa Puzzolo,Antonello Mallamaci
Elisa Puzzolo
Background: The metatherian Monodelphis domestica, commonly known as the South-American short-tailed opossum, is an appealing animal model for developmental studies on cortico-cerebral development. Given its phylogenetic ...
Insulin receptor signaling in the development of neuronal structure and function [0.03%]
胰岛素受体信号在神经元结构和功能发育中的作用
Shu-Ling Chiu,Hollis T Cline
Shu-Ling Chiu
Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit signals within the neuronal networ...
Nav2 is necessary for cranial nerve development and blood pressure regulation [0.03%]
Nav2通道在颅神经发育和血压调节中是必需的
Elizabeth M McNeill,Kenneth P Roos,Dieder Moechars et al.
Elizabeth M McNeill et al.
Background: All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neurobla...
Remodeling of inhibitory synaptic connections in developing ferret visual cortex [0.03%]
正在发育的雪貂视觉皮层中抑制性突触连接的改建
Matthew B Dalva
Matthew B Dalva
Background: In the visual cortex, as in many other regions of the developing brain, excitatory synaptic connections undergo substantial remodeling during development. While evidence suggests that local inhibitory synapses...
The unfulfilled gene is required for the development of mushroom body neuropil in Drosophila [0.03%]
未 fulfilled基因是果蝇新皮层神经元发育所必需的
Karen E Bates,Carl S Sung,Steven Robinow
Karen E Bates
Background: The mushroom bodies (MBs) of Drosophila are required for complex behaviors and consist of three types of neurons, gamma, alpha'/beta' and alpha/beta. Previously, roles for transcription factors in MB neuronal ...
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation [0.03%]
Brn3a通过促进感觉分化期间Runx的表达来调节三叉神经ganglion中神经元亚型的规格
Iain M Dykes,Jason Lanier,S Raisa Eng et al.
Iain M Dykes et al.
The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second m...
Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system [0.03%]
慢性暴露于高浓度促炎症细胞因子对发育中的视觉系统神经发育的影响
Ryan H Lee,Elizabeth A Mills,Neil Schwartz et al.
Ryan H Lee et al.
Background: Imbalances in the regulation of pro-inflammatory cytokines have been increasingly correlated with a number of severe and prevalent neurodevelopmental disorders, including autism spectrum disorder, schizophreni...
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis [0.03%]
非洲爪蟾神经嵴发育的新调节因子F框蛋白Cdc4/Fbxw7
Alexandra D Almeida,Helen M Wise,Christopher J Hindley et al.
Alexandra D Almeida et al.
Background: The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of deri...
Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain [0.03%]
果蝇脑中移植扩增神经前体细胞系的幼虫后发育过程研究
Natalya Izergina,Jasmin Balmer,Bruno Bello et al.
Natalya Izergina et al.
Background: Specific dorsomedial (DM) neuroblast lineages of the Drosophila brain amplify their proliferation through generation of transit amplifying intermediate progenitor cells. Together, these DM neuroblast lineages ...
Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice [0.03%]
Nfib缺陷小鼠半球间皮质联系发育障碍的多因素非自主调控机制研究
Michael Piper,Randal X Moldrich,Charlotta Lindwall et al.
Michael Piper et al.
Background: Agenesis of the corpus callosum is associated with many human developmental syndromes. Key mechanisms regulating callosal formation include the guidance of axons arising from pioneering neurons in the cingulat...