Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα [0.03%]
甲状腺激素通过RORα诱导Purkinje细胞早期树突分化
Fatiha Boukhtouche,Bernard Brugg,Rosine Wehrlé et al.
Fatiha Boukhtouche et al.
Background: The active form (T3) of thyroid hormone (TH) controls critical aspects of cerebellar development, such as migration of postmitotic neurons and terminal dendritic differentiation of Purkinje cells. The effects ...
Ependymal alterations in sudden intrauterine unexplained death and sudden infant death syndrome: possible primary consequence of prenatal exposure to cigarette smoking [0.03%]
宫内突然不明原因死亡和婴儿猝死综合征中的室管膜细胞改变：可能是孕期暴露于香烟吸烟的直接后果
Anna M Lavezzi,Melissa F Corna,Luigi Matturri
Anna M Lavezzi
Background: The ependyma, the lining providing a protective barrier and filtration system separating brain parenchyma from cerebrospinal fluid, is still inadequately understood in humans. In this study we aimed to define,...
Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II [0.03%]
缝隙连接和Netrin-1通过Rho激酶、肌球蛋白轻链激酶和肌球蛋白II引导颅神经运动轴突生长路径
Ailish Murray,Arifa Naeem,Sarah H Barnes et al.
Ailish Murray et al.
Background: In the developing hindbrain, cranial motor axon guidance depends on diffusible repellent factors produced by the floor plate. Our previous studies have suggested that candidate molecules for mediating this eff...
Assembly of the outer retina in the absence of GABA synthesis in horizontal cells [0.03%]
视网膜水平细胞缺乏GABA合成时外视网膜的组装
Timm Schubert,Rachel M Huckfeldt,Edward Parker et al.
Timm Schubert et al.
Background: The inhibitory neurotransmitter gamma-amino-butyric acid (GABA) not only modulates excitability in the mature nervous system but also regulates neuronal differentiation and circuit development. Horizontal cell...
Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala [0.03%]
表达并响应 Sonic hedgehog 的细胞在中央杏仁核产生神经元多样性
Rosalind S E Carney,Jean-Marie Mangin,Lindsay Hayes et al.
Rosalind S E Carney et al.
Background: The mammalian amygdala is composed of two primary functional subdivisions, classified according to whether the major output projection of each nucleus is excitatory or inhibitory. The posterior dorsal and vent...
Comparative Study
Neural development. 2010 May 27:5:14. DOI:10.1186/1749-8104-5-14 2010
FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm [0.03%]
FGF依赖的Zfhx1b基因表达调控促进小鼠前神经外胚层确定性神经干细胞形成
Lan T H Dang,Vincent Tropepe
Lan T H Dang
Background: Mouse definitive neural stem cells (NSCs) are derived from a population of LIF-responsive primitive neural stem cells (pNSCs) within the neurectoderm, yet details on the early signaling and transcriptional mec...
Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development [0.03%]
斑马鱼dync1h1突变体的分析揭示了细胞质动力蛋白1在视网膜光受器发育过程中的多种功能
Christine Insinna,Lisa M Baye,Adam Amsterdam et al.
Christine Insinna et al.
Background: Photoreceptors of the retina are highly compartmentalized cells that function as the primary sensory neurons for receiving and initiating transmission of visual information. Proper morphogenesis of photorecept...
Pharmacological manipulation of GABA-driven activity in ovo disrupts the development of dendritic morphology but not the maturation of spinal cord network activity [0.03%]
在卵黄期药理学上操纵GABA能活性会破坏树突形态的发展但不会破坏脊髓网络活动的成熟过程
Yone J Yoon,Alexander P Gokin,Miguel Martin-Caraballo
Yone J Yoon
Background: In the adult nervous system, GABA acts as a major inhibitory neurotransmitter; however, at early stages of neurodevelopment, GABA receptor activation leads to membrane depolarization and accumulation of [Ca2+]...
Dynamics of glutamatergic signaling in the mushroom body of young adult Drosophila [0.03%]
年轻成年果蝇蘑菇体中的谷氨酸能信号动力学
Irina Sinakevitch,Yves Grau,Nicholas J Strausfeld et al.
Irina Sinakevitch et al.
Background: The mushroom bodies (MBs) are paired brain centers located in the insect protocerebrum involved in olfactory learning and memory and other associative functions. Processes from the Kenyon cells (KCs), their in...
The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain [0.03%]
小胶质细胞基底膜作为神经元迁移的边界和衬底在斑马鱼延髓中的作用研究
Paul K Grant,Cecilia B Moens
Paul K Grant
Background: The facial branchiomotor neurons of cranial nerve VII undergo a stereotyped tangential migration in the zebrafish hindbrain that provides an ideal system for examining the complex interactions between neurons ...