In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells [0.03%]
野生型和位置错乱的视网膜节细胞中树突取向的体内发育动态
Jung-Hwan Choi,Mei-Yee Law,Chi-Bin Chien et al.
Jung-Hwan Choi et al.
Background: Many neurons in the central nervous system, including retinal ganglion cells (RGCs), possess asymmetric dendritic arbors oriented toward their presynaptic partners. How such dendritic arbors become biased duri...
Darius Camp,Ko Currie,Alain Labbé et al.
Darius Camp et al.
Background: The Hedgehog (Hh) signaling pathway is important for the development of a variety of tissues in both vertebrates and invertebrates. For example, in developing nervous systems Hh signaling is required for the n...
RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer [0.03%]
在外部胚基由Hh通路活化引起的颗粒神经元前体发育和髓母细胞瘤形成过程中不需要RBP-J
Elaine Julian,Andrew R Hallahan,Brandon J Wainwright
Elaine Julian
Background: The Notch signalling pathway plays crucial roles in neural development, functioning by preventing premature differentiation and promotion of glial cell fates. In the developing cerebellum Notch pathway compone...
Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex [0.03%]
果蝇II型神经干细胞系维持低Prospero水平以生成大量克隆并参与成年大脑中央复合体的构建
Omer Ali Bayraktar,Jason Q Boone,Michael L Drummond et al.
Omer Ali Bayraktar et al.
Tissue homeostasis depends on the ability of stem cells to properly regulate self-renewal versus differentiation. Drosophila neural stem cells (neuroblasts) are a model system to study self-renewal and differentiation. Recent work has ident...
Context-dependent functions of specific microRNAs in neuronal development [0.03%]
特定微小RNA在神经元发育中的功能取决于环境条件
Fen-Biao Gao
Fen-Biao Gao
MicroRNAs (miRNAs) are small noncoding RNAs that regulate multiple developmental processes at the post-transcriptional level. Recent rapid progresses have demonstrated critical roles for a number of miRNAs in neuronal development and functi...
Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development [0.03%]
斑马鱼发育过程中复杂素3和4在含有带状结构的感觉神经元中的富集及不同定位
George Zanazzi,Gary Matthews
George Zanazzi
Background: In sensory systems with broad bandwidths, polarized receptor cells utilize highly specialized organelles in their apical and basolateral compartments to transduce and ultimately transmit signals to the rest of...
Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum [0.03%]
小鼠侧小脑早期/后出生的浦肯野细胞的迁移、早期轴突发生和Reelin依赖性层形成行为
Takaki Miyata,Yuichi Ono,Mayumi Okamoto et al.
Takaki Miyata et al.
Background: Cerebellar corticogenesis begins with the assembly of Purkinje cells into the Purkinje plate (PP) by embryonic day 14.5 (E14.5) in mice. Although the dependence of PP formation on the secreted protein Reelin i...
Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system [0.03%]
Meis1规定了视网膜和顶盖中的位置信息以组织斑马鱼视觉系统
Timothy Erickson,Curtis R French,Andrew J Waskiewicz
Timothy Erickson
Background: During visual system development, multiple signalling pathways cooperate to specify axial polarity within the retina and optic tectum. This information is required for the topographic mapping of retinal gangli...
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling [0.03%]
Nolz1通过调节视黄酸信号促进纹状体神经发生
Noelia Urbán,Raquel Martín-Ibáñez,Cristina Herranz et al.
Noelia Urbán et al.
Background: Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown. ...
Alexandra M Miller,Lydia R Maurer,Dong-Jing Zou et al.
Alexandra M Miller et al.
Olfactory sensory neuron (OSN) axons exit the olfactory epithelium (OE) and extend toward the olfactory bulb (OB) where they coalesce into glomeruli. Each OSN expresses only 1 of approximately 1,200 odor receptors (ORs). OSNs expressing the...