Melissa M Langworthy,Bruce Appel
Melissa M Langworthy
Background: Interaction of Schwann cells with axons triggers signal transduction that drives expression of Pou3f1 and Egr2 transcription factors, which in turn promote myelination. Signal transduction appears to be mediat...
RabGDI controls axonal midline crossing by regulating Robo1 surface expression [0.03%]
RabGDI通过调节Robo1表面表达来控制轴突中线穿越
Melanie Philipp,Vera Niederkofler,Marc Debrunner et al.
Melanie Philipp et al.
Background: Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from at...
Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics [0.03%]
斑马鱼Mnx蛋白决定一种运动神经元亚型并抑制中间神经元表型的获得
Steve D Seredick,Liesl Van Ryswyk,Sarah A Hutchinson et al.
Steve D Seredick et al.
Background: Precise matching between motoneuron subtypes and the muscles they innervate is a prerequisite for normal behavior. Motoneuron subtype identity is specified by the combination of transcription factors expressed...
Sarah E Hill,Manpreet Parmar,Kyle W Gheres et al.
Sarah E Hill et al.
Background: Drosophila neurons have dendrites that contain minus-end-out microtubules. This microtubule arrangement is different from that of cultured mammalian neurons, which have mixed polarity microtubules in dendrites...
Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina [0.03%]
Midkine-A通过上游调节Id2a来调控发育脊椎动物视网膜中的细胞周期动力学
Jing Luo,Rosa A Uribe,Sarah Hayton et al.
Jing Luo et al.
Background: Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb). In th...
Morphogenesis underlying the development of the everted teleost telencephalon [0.03%]
侧纹亚纲端脑外翻的发育发生机制研究
Mónica Folgueira,Philippa Bayley,Pavla Navratilova et al.
Mónica Folgueira et al.
Background: Although the mechanisms underlying brain patterning and regionalization are very much conserved, the morphology of different brain regions is extraordinarily variable across vertebrate phylogeny. This is espec...
Ultrabithorax confers spatial identity in a context-specific manner in the Drosophila postembryonic ventral nervous system [0.03%]
Ultrabithorax 以特定的背景方式赋予拟南芥后胚胎期腹神经系统的空间特异性
Elizabeth C Marin,Katie E Dry,Danielle R Alaimo et al.
Elizabeth C Marin et al.
Background: In holometabolous insects such as Drosophila melanogaster, neuroblasts produce an initial population of diverse neurons during embryogenesis and a much larger set of adult-specific neurons during larval life. ...
β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina [0.03%]
β-catenin/Wnt信号通路控制斑马鱼发育和再生视网膜祖细胞的命运
Jason R Meyers,Lily Hu,Ariel Moses et al.
Jason R Meyers et al.
Background: The zebrafish retina maintains two populations of stem cells: first, the germinal zone or ciliary marginal zone (CMZ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fis...
Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system [0.03%]
协调的Eph-ephrin信号指引avian听觉系统中的迁移和轴突目标定位
Michelle R Allen-Sharpley,Karina S Cramer
Michelle R Allen-Sharpley
Background: In the avian sound localization circuit, nucleus magnocellularis (NM) projects bilaterally to nucleus laminaris (NL), with ipsilateral and contralateral NM axon branches directed to dorsal and ventral NL dendr...
Neurog1 and Neurog2 coordinately regulate development of the olfactory system [0.03%]
神经元发生基因1和神经元发生基因2协同调节嗅觉系统的发育
Tarek Shaker,Daniel Dennis,Deborah M Kurrasch et al.
Tarek Shaker et al.
Background: Proneural genes encode basic helix-loop-helix transcription factors that specify distinct neuronal identities in different regions of the nervous system. In the embryonic telencephalon, the proneural genes Neu...