Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons [0.03%]
活体皮层神经元中神经突触蛋白依赖的突触前末端组装的动态机制研究
Luke Ad Bury,Shasta L Sabo
Luke Ad Bury
Background: Synapse formation occurs when synaptogenic signals trigger coordinated development of pre and postsynaptic structures. One of the best-characterized synaptogenic signals is trans-synaptic adhesion. However, it...
Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages [0.03%]
非洲爪蟾脊髓损伤的基因表达谱揭示了再生和非再生阶段之间的广泛差异
Dasfne Lee-Liu,Mauricio Moreno,Leonardo I Almonacid et al.
Dasfne Lee-Liu et al.
Background: Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during ...
Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice [0.03%]
延迟的神经发生会导致白化小鼠腹侧视网膜节细胞规格异常
Punita Bhansali,Ilana Rayport,Alexandra Rebsam et al.
Punita Bhansali et al.
Background: Proper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the...
RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons [0.03%]
RPM-1定位于不同的细胞器并且调节GABA能运动神经元的轴突长度
Karla J Opperman,Brock Grill
Karla J Opperman
Background: The PAM/Highwire/RPM-1 (PHR) proteins are conserved signaling proteins that regulate axon length and synapse formation during development. Loss of function in Caenorhabditis elegans rpm-1 results in axon termi...
Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo [0.03%]
原肠胚中胚层在斑马鱼神经板细胞活体运动中的作用
Claudio Araya,Marcel Tawk,Gemma C Girdler et al.
Claudio Araya et al.
Background: Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they conv...
Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development [0.03%]
斑马鱼rtn4/Nogo同源基因在胚胎发育中的重要作用
Alejandro Pinzón-Olejua,Cornelia Welte,Houari Abdesselem et al.
Alejandro Pinzón-Olejua et al.
Background: As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs-M1 to M4-in the N-terminal region of m...
LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5 [0.03%]
LPHN3调节新皮层第2/3层至第5层突触输入的强度，这是一种与注意缺陷多动障碍有关的前突触粘附G蛋白偶联受体
Matthew L O&#x;Sullivan,Francesca Martini,Sventja von Daake et al.
Matthew L O&#x;Sullivan et al.
Background: Latrophilins (LPHNs) are a small family of neuronal adhesion-GPCRs originally discovered as receptors for the black widow spider toxin α-latrotoxin. Mutations in LPHN3 have recently been identified as risk fa...
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex [0.03%]
多个保守的调节域促进Fezf2在发育大脑皮层中的表达
Matthew J Eckler,Kathryn A Larkin,William L McKenna et al.
Matthew J Eckler et al.
Background: The genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poor...
Biliana O Veleva-Rotse,James L Smart,Annette F Baas et al.
Biliana O Veleva-Rotse et al.
Background: Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is req...
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells [0.03%]
atonal在祖细胞中的功能对Drosophila运动检测神经元的正确连接是必需的
Carlos Oliva,Ching-Man Choi,Laura J J Nicolai et al.
Carlos Oliva et al.
Background: Vertebrates and invertebrates obtain visual motion information by channeling moving visual cues perceived by the retina through specific motion sensitive synaptic relays in the brain. In Drosophila, the series...