Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex [0.03%]
Bacurd2是Rnd2的新相互作用伴侣，可控制发育哺乳动物大脑皮层中的径向迁移
Ivan Enghian Gladwyn-Ng,Shan Shan Li,Zhengdong Qu et al.
Ivan Enghian Gladwyn-Ng et al.
Background: During fetal brain development in mammals, newborn neurons undergo cell migration to reach their appropriate positions and form functional circuits. We previously reported that the atypical RhoA GTPase Rnd2 pr...
Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling [0.03%]
视黄茋Hh信号响应的时空差异决定了斑马鱼眼睛的背腹模式化
Xiumei Wang,Giuseppe Lupo,Rongqiao He et al.
Xiumei Wang et al.
Background: Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity. There has been limited analy...
Comparative Study
Neural development. 2015 Mar 20:10:7. DOI:10.1186/s13064-015-0035-9 2015
Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones [0.03%]
导向纤毛中线索诱导局部蛋白质合成的F肌动蛋白和微管细胞骨架的不同需求
Michael Piper,Aih Cheun Lee,Francisca P G van Horck et al.
Michael Piper et al.
Background: Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not kn...
Comparative Study
Neural development. 2015 Feb 25:10:3. DOI:10.1186/s13064-015-0031-0 2015
Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder [0.03%]
自闭症谱系障碍小鼠模型的大脑皮层功能区形成受损
Laura R Fenlon,Sha Liu,Ilan Gobius et al.
Laura R Fenlon et al.
Background: Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biologi...
Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye [0.03%]
Polycomb基因群基因对于维持果蝇眼睛二元命运决定是必需的
Jennifer K Finley,Adam C Miller,Tory G Herman
Jennifer K Finley
Background: Identifying the mechanisms by which cells remain irreversibly committed to their fates is a critical step toward understanding and being able to manipulate development and homeostasis. Polycomb group (PcG) pro...
Comparative Study
Neural development. 2015 Jan 31:10:2. DOI:10.1186/s13064-015-0029-7 2015
Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures [0.03%]
皮层和海马神经网络中爆发活动动力学的差异性研究
Paul Charlesworth,Ellese Cotterill,Andrew Morton et al.
Paul Charlesworth et al.
Background: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had...
Comparative Study
Neural development. 2015 Jan 28;10(1):1. DOI:10.1186/s13064-014-0028-0 2015
Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling [0.03%]
Sox2和Wnt信号协作建立小眼病鼠视网膜神经生成区域 граница神经系统生成区域的建立需要Sox2和Wnt信号之间的合作
Whitney E Heavner,Cynthia L Andoniadou,Larysa H Pevny
Whitney E Heavner
Background: Eye development in vertebrates relies on the critical regulation of SOX2 expression. Humans with mutations in SOX2 often suffer from eye defects including anophthalmia (no eye) and microphthalmia (small eye). ...
Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons [0.03%]
小脑颗粒神经元径向迁移过程中领导边进程肌动蛋白协调细胞器定位和黏附受体动力学
Niraj Trivedi,Joseph S Ramahi,Mahmut Karakaya et al.
Niraj Trivedi et al.
Background: During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) ...
Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity [0.03%]
在视网膜自发性图案化活动受干扰后，特异于眼睛的视网膜-外侧膝状体节段正常进行
Colenso M Speer,Chao Sun,Lauren C Liets et al.
Colenso M Speer et al.
Background: Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but the feature(s) of activity critical for retinogeniculate refinement are ...
Rachael Lumb,Sophie Wiszniak,Samuela Kabbara et al.
Rachael Lumb et al.
Background: Neural crest cells (NCCs) are a transient embryonic cell type that give rise to a wide spectrum of derivatives, including neurons and glia of the sensory and autonomic nervous system, melanocytes and connectiv...