Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish [0.03%]
斑马鱼视网膜节细胞分化过程中初级纤毛的特征研究
Paola Lepanto,Camila Davison,Gabriela Casanova et al.
Paola Lepanto et al.
Background: Retinal ganglion cell (RGC) differentiation in vivo is a highly stereotyped process, likely resulting from the interaction of cell type-specific transcription factors and tissue-derived signaling factors. The ...
Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development [0.03%]
Wnt/β-catenin诱导的mir-135a-2位点在胚胎前脑发育中的表达和功能分析
Giuliana Caronia-Brown,Angela Anderegg,Rajeshwar Awatramani
Giuliana Caronia-Brown
Background: Brain size and patterning are dependent on dosage-sensitive morphogen signaling pathways - yet how these pathways are calibrated remains enigmatic. Recent studies point to a new role for microRNAs in tempering...
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration [0.03%]
PHR蛋白：神经元发育和轴突变性的细胞内信号传导中心
Brock Grill,Rodney K Murphey,Melissa A Borgen
Brock Grill
During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR pr...
Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons [0.03%]
Bacurd1/Kctd13 和 Bacurd2/Tnfaip1 通过影响Rnd蛋白与大脑皮层神经元长期定位及树突成熟有关并相互作用
Ivan Gladwyn-Ng,Lieven Huang,Linh Ngo et al.
Ivan Gladwyn-Ng et al.
Background: The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat...
Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism [0.03%]
Evx1和Evx2通过Pax2非依赖机制指定兴奋性神经元类型并抑制抑制性神经元类型的产生
José L Juárez-Morales,Claus J Schulte,Sofia A Pezoa et al.
José L Juárez-Morales et al.
Background: For neurons to function correctly in neuronal circuitry they must utilize appropriate neurotransmitters. However, even though neurotransmitter specificity is one of the most important and defining properties o...
Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation [0.03%]
生长分化因子-5在交感神经支配建立中的区域特异性作用
Gerard W O&#x;Keeffe,Humberto Gutierrez,Laura Howard et al.
Gerard W O&#x;Keeffe et al.
Background: Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympat...
Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick [0.03%]
识别发育鸡胚胎中不同颅神经感觉神经节的分子特征
Cedric Patthey,Harry Clifford,Wilfried Haerty et al.
Cedric Patthey et al.
Background: The cranial sensory ganglia represent populations of neurons with distinct functions, or sensory modalities. The production of individual ganglia from distinct neurogenic placodes with different developmental ...
Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development [0.03%]
CMT2B相关Rab7突变在脊椎动物感觉神经元发育过程中引起轴突生长和导向缺陷
Olga Y Ponomareva,Kevin W Eliceiri,Mary C Halloran
Olga Y Ponomareva
Background: Charcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, pr...
Microtubule-associated protein 1b is required for shaping the neural tube [0.03%]
微管相关蛋白1b是神经管塑形所必需的
Pradeepa Jayachandran,Valerie N Olmo,Stephanie P Sanchez et al.
Pradeepa Jayachandran et al.
Background: Shaping of the neural tube, the precursor of the brain and spinal cord, involves narrowing and elongation of the neural tissue, concomitantly with other morphogenetic changes that contribue to this process. In...
Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation [0.03%]
Notch-Hairy/E(Spl)信号转导通路抑制Deltex1并诱导神经元和胶质细胞分化
Yi-Chuan Cheng,Yin-Cheng Huang,Tu-Hsueh Yeh et al.
Yi-Chuan Cheng et al.
Background: Notch signaling has been conserved throughout evolution and plays a fundamental role in various neural developmental processes and the pathogenesis of several human cancers and genetic disorders. However, how ...