Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1 [0.03%]
Ascl1对胚胎下丘脑 tuberal区域少突胶质细胞发育的影响
Candace M Marsters,Jessica M Rosin,Hayley F Thornton et al.
Candace M Marsters et al.
Background: Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro...
Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord [0.03%]
Netrin1/DCC信号促进背侧脊髓神经元迁移
Harald J Junge,Andrea R Yung,Lisa V Goodrich et al.
Harald J Junge et al.
Background: Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during de...
Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling [0.03%]
Slit/Robo信号调控对侧运动神经元迁移入眼帘层
Brielle Bjorke,Farnaz Shoja-Taheri,Minkyung Kim et al.
Brielle Bjorke et al.
Background: Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo...
Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern [0.03%]
皮层小清蛋白阳性颗粒细胞亚群的发育时间决定了小脑叶片模式生成的时间框架和空间分布
Emilie Legué,Jackie L Gottshall,Edouard Jaumouillé et al.
Emilie Legué et al.
Background: The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...
Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons [0.03%]
Lmx1b基因对脊髓中一类神经元向谷氨酸能神经元分化命运决定至关重要
William C Hilinski,Jonathan R Bostrom,Samantha J England et al.
William C Hilinski et al.
Background: Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...
In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains [0.03%]
果蝇Robo1免疫球蛋白样的结构域的功能分析
Marie C Reichert,Haley E Brown,Timothy A Evans
Marie C Reichert
Background: In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a...
Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits [0.03%]
用Xenopus蝌蚪发育中的视顶盖条件性敲低FMRP会增强前馈抑制并导致行为缺陷
Torrey L S Truszkowski,Eric J James,Mashfiq Hasan et al.
Torrey L S Truszkowski et al.
Background: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...
Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells [0.03%]
双亮氨酸拉链激酶调节小鼠神经细胞中轴突导向基因的表达
Andréanne Blondeau,Jean-François Lucier,Dominick Matteau et al.
Andréanne Blondeau et al.
Background: Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. H...
Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei [0.03%]
视前核Dbx1衍生神经元的分子和行为特征分析
Katie Sokolowski,Tuyen Tran,Shigeyuki Esumi et al.
Katie Sokolowski et al.
Background: Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ...
The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation [0.03%]
肝糖胺聚糖缺乏在自闭症表型中的作用：Slit/Robo/srGAPs介导的树突棘形成可能起重要作用
Christine Pérez,Darrell Sawmiller,Jun Tan
Christine Pérez
Autism Spectrum Disorders (ASD) are the second most common developmental cause of disability in the United States. ASDs are accompanied with substantial economic and emotional cost. The brains of ASD patients have marked structural abnormal...