Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex [0.03%]
Rp58和p27kip1在胚胎小鼠脑皮层中协调细胞周期退出和神经元迁移
Olivier Clément,Isabel Anne Hemming,Ivan Enghian Gladwyn-Ng et al.
Olivier Clément et al.
Background: During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriatel...
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia [0.03%]
Afadin控制发育皮质放射状胶质细胞的极化和有丝分裂纺锤体取向
Jennifer Rakotomamonjy,Molly Brunner,Christoph Jüschke et al.
Jennifer Rakotomamonjy et al.
Background: In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly po...
Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance [0.03%]
线粒体DNA多态性影响非酒精性脂肪肝疾病患者的胰岛素抵抗程度
Manuela D Mitsogiannis,Graham E Little,Kevin J Mitchell
Manuela D Mitsogiannis
Background: Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into speciali...
Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis [0.03%]
肌球蛋白Kif20b突变造成皮层神经元极化和形态建成缺陷
Katrina C McNeely,Timothy D Cupp,Jessica Neville Little et al.
Katrina C McNeely et al.
Background: How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar...
Lacking of palladin leads to multiple cellular events changes which contribute to NTD [0.03%]
Palladin缺失导致的多种细胞事件改变可引发NTD发生
Juan Tan,Xue-Jiao Chen,Chun-Ling Shen et al.
Juan Tan et al.
Background: The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi...
The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development [0.03%]
微管正端结合蛋白TACC3促进轴突的持续生长并介导发育过程中轴突导向信号反应
Burcu Erdogan,Garrett M Cammarata,Eric J Lee et al.
Burcu Erdogan et al.
Background: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t...
Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons [0.03%]
神经发生的时间差异决定了嗅觉感觉神经元的背腹位向性投射
Eerdunfu,Naoki Ihara,Bao Ligao et al.
Eerdunfu et al.
Background: The mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE...
The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity [0.03%]
Hunchback转录因子建立但不是维持早生成神经元身份的必需因素
Keiko Hirono,Minoree Kohwi,Matt Q Clark et al.
Keiko Hirono et al.
Background: Drosophila and mammalian neural progenitors typically generate a diverse family of neurons in a stereotyped order. Neuronal diversity can be generated by the sequential expression of temporal transcription fac...
Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain [0.03%]
脊椎动物大脑神经发生初期促进神经转录因子对下游神经元基因的调控
Michelle Ware,Houda Hamdi-Rozé,Julien Le Friec et al.
Michelle Ware et al.
Background: Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ...
Peter J Bosch,Leah C Fuller,Carolyn M Sleeth et al.
Peter J Bosch et al.
Background: The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel...