Favorable safety profile of moderate hypofractionated over normofractionated radiotherapy in breast cancer patients: a multicentric prospective real-life data farming analysis [0.03%]
中等程度低分割放疗较常规分割放疗可改善乳腺癌患者的预后：一项多中心前瞻性真实世界数据分析
Irfane Issoufaly,Claire Petit,Sébastien Guihard et al.
Irfane Issoufaly et al.
Background: Moderately hypofractionated whole-breast radiotherapy (HFRT) has proven to be as safe and efficient as normofractionated radiotherapy (NFRT) in randomized trials resulting in major changes in clinical practice...
Applying pytorch toolkit to plan optimization for circular cone based robotic radiotherapy [0.03%]
基于机器人放射治疗的圆形锥束规划优化的PyTorch工具包的应用研究
Bin Liang,Ran Wei,Jianghu Zhang et al.
Bin Liang et al.
Background: Robotic linac is ideally suited to deliver hypo-fractionated radiotherapy due to its compact head and flexible positioning. The non-coplanar treatment space improves the delivery versatility but the complexity...
Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy [0.03%]
胶质母细胞瘤细胞治疗抵抗和转录组谱系整合分析发现联合放化疗增敏弱点
Leon Emanuel Schnöller,Valerie Albrecht,Nikko Brix et al.
Leon Emanuel Schnöller et al.
Background: Inherent resistance to radio/chemotherapy is one of the major reasons for early recurrence, treatment failure, and dismal prognosis of glioblastoma. Thus, the identification of resistance driving regulators as...
Stereotactic MRI-guided radiation therapy for localized prostate cancer (SMILE): a prospective, multicentric phase-II-trial [0.03%]
立体定向磁共振引导的放疗治疗局限性前列腺癌（微笑试验）：一项前瞻性多中心II期临床试验
J Ristau,J Hörner-Rieber,C Buchele et al.
J Ristau et al.
Background: Normofractionated radiation regimes for definitive prostate cancer treatment usually extend over 7-8 weeks. Recently, moderate hypofractionation with doses per fraction between 2.2 and 4 Gy has been shown to b...
Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications [0.03%]
便携式低氧室的开发用于超高剂量率的激光驱动质子辐射生物学研究应用程序
Pankaj Chaudhary,Deborah C Gwynne,Boris Odlozilik et al.
Pankaj Chaudhary et al.
Background: There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect ob...
Applicability of a pathological complete response magnetic resonance-based radiomics model for locally advanced rectal cancer in intercontinental cohort [0.03%]
基于磁共振的影像组学模型在不同人种局晚直肠癌患者中的适用性研究
Luca Boldrini,Jacopo Lenkowicz,Lucia Clara Orlandini et al.
Luca Boldrini et al.
Background: Predicting pathological complete response (pCR) in patients affected by locally advanced rectal cancer (LARC) who undergo neoadjuvant chemoradiotherapy (nCRT) is a challenging field of investigation, but many ...
Retrospective evaluation of a robust hybrid planning technique established for irradiation of breast cancer patients with included mammary internal lymph nodes [0.03%]
回顾性评估用于包含乳房内部淋巴结的乳腺癌患者放射治疗的稳健混合计划技术
Marina Hennet,Stephan Radonic,Uwe Schneider et al.
Marina Hennet et al.
Background: The irradiation of breast cancer patients with included internal mammary lymph nodes challenges radiation planning with regard to robustness and protection of OARs. In this publication, a feasible hybrid radia...
Predicting 2-year survival in stage I-III non-small cell lung cancer: the development and validation of a scoring system from an Australian cohort [0.03%]
基于澳大利亚队列的I-III期非小细胞肺癌患者两年生存预测评分系统的构建及验证
Natalie Si-Yi Lee,Jesmin Shafiq,Matthew Field et al.
Natalie Si-Yi Lee et al.
Background: There are limited data on survival prediction models in contemporary inoperable non-small cell lung cancer (NSCLC) patients. The objective of this study was to develop and validate a survival prediction model ...
Transparency in quality of radiotherapy for breast cancer in the Netherlands: a national registration of radiotherapy-parameters [0.03%]
荷兰乳腺癌放射治疗质量透明度全国登记调查研究报告
Nansi Maliko,Marcel R Stam,Liesbeth J Boersma et al.
Nansi Maliko et al.
Background: Radiotherapy (RT) is part of the curative treatment of approximately 70% of breast cancer (BC) patients. Wide practice variation has been reported in RT dose, fractionation and its treatment planning for BC. T...
Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation [0.03%]
甘那替匹普选择性地使癌症细胞对近端和远端展开布拉格峰值质子辐射敏感化
Simon Deycmar,Elisabeth Mara,Sylvia Kerschbaum-Gruber et al.
Simon Deycmar et al.
Objective: Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for ...