Efficient prime editing in vivo and in vitro using lipid nanoparticles [0.03%]
使用脂质纳米颗粒在体内和体外高效进行基因prime编辑
Allen Y Jiang,Ana Cristian,Dominique L Brooks et al.
Allen Y Jiang et al.
Prime editing is a versatile clinical genome editing method that enables precise substitutions, small insertions and deletions at specified locations in the genomes of living systems including human cells. Although non-viral lipid nanoparti...
Link between thermodynamic correlation signatures and superconductivity in twisted trilayer graphene [0.03%]
扭曲三层石墨烯中热力学相关特征与超导电性的关联关系研究
Jesse C Hoke,Yifan Li,Yuwen Hu et al.
Jesse C Hoke et al.
Twisted graphene multilayers exhibit strong electronic correlations leading to a range of experimental signatures. Yet how these signatures relate to each other and to the microscopic ground states-and how twist angle and band structure res...
Programmed synthesis of mesoporous protein crystals in cellular reactors [0.03%]
细胞反应器中合成介孔蛋白质晶体的方法及应用
Hongru Yang,Dian-Zhao Lin,Zhe Li et al.
Hongru Yang et al.
Protein crystals are naturally derived mesoporous materials with versatile structures and physicochemical properties. Here we introduce an intracellular synthesis platform that enables controllable and programmable protein crystallization. ...
Wei Nie,Hong-Jia Wang,Yuying Gao et al.
Wei Nie et al.
Water oxidation, widely recognized as the kinetic bottleneck of artificial photosynthesis, limits solar fuel efficiency. Despite progress in elucidating reaction mechanisms and theoretical predictions, the dynamic spatial coupling of charge...
Anomalous ultrafast lithium-ion transport through boron nitride nanotube membranes [0.03%]
异常的超快锂离子通过氮化硼纳米管膜传输
Semih Cetindag,Aaditya Pendse,Pavel Rehak et al.
Semih Cetindag et al.
Here we studied the aqueous transport of different alkali-metal ions in charged boron nitride nanotubes (BNNTs) and compared the results with those obtained in carbon nanotubes, using macroscopic, vertically aligned nanotube membranes at de...
Weiwen Xin,Xiang-Yu Kong,Liping Wen
Weiwen Xin
Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels [0.03%]
借助附近血管的增强渗透能力纳米颗粒到达转移性肿瘤
Qin Wang,Cici Zeng,Ziqi Chen et al.
Qin Wang et al.
Considering that 90% of cancer-related deaths are due to metastasis, treating micrometastases in their infancy is critical. Targeting micrometastases with nanoparticles has shown therapeutic potential, but a limited understanding of the del...
Activating a B cell immune response regresses immunologically cold tumours [0.03%]
激活B细胞免疫反应可使“冷肿瘤”消退
Heena Aggarwal,Nimish Gupta,Aniruddha Sengupta et al.
Heena Aggarwal et al.
Progress in immuno-oncology has been stymied by poorly immunogenic 'cold' tumours and the focus on T cells at the cost of other immune cells. Here we report that AT-1965, a small molecule in a lipid nanoparticle, induces rapid regression of...
Lucy S Britto,Ankur Singh
Lucy S Britto
Sovanny R Taylor,Paulo L Onuchic,Steven Boeynaems
Sovanny R Taylor