Superionic composite electrolytes with continuously perpendicular-aligned pathways for pressure-less all-solid-state lithium batteries [0.03%]
具有连续垂直排列通道的超离子复合电解质用于无压全固态锂电池
Xuexia Lan,Zhen Li,Chao Zhao et al.
Xuexia Lan et al.
Solid electrolytes are promising candidates for safe, high-energy battery systems. Composite solid electrolytes, in particular, hold the potential to combine high ionic conductivity with stable electrode interfaces. However, a fundamental t...
Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis [0.03%]
靶向关节软骨损伤且作用效果与损伤程度响应相关的RNA药物递送纳米粒子疗法
Claudio Intini,Fergal J O&#x;Brien
Claudio Intini
A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis [0.03%]
一种针对疾病严重程度的纳米粒子能有效治疗骨关节炎中的生长激素释放肽信使RNA疗法
Mahima Dewani,Anjali Rajesh Mamidwar,Miraj Rawal et al.
Mahima Dewani et al.
Intra-articular RNA therapeutics have shown promise in osteoarthritis (OA); however, maximizing their efficacy requires targeted delivery to degenerating cartilage within focal lesions. As OA progresses, cartilage degeneration worsens, nece...
A cryogenic near-field thermal diode leveraging superconducting phase transitions [0.03%]
一种利用超导相变的低温近场热二极管
Yuxuan Luan,Shen Yan,Jian Guan et al.
Yuxuan Luan et al.
Control of charge and heat transport is essential for computing and thermal management technologies. Recent work with superconducting materials has shown rectified electrical supercurrents near liquid helium temperatures. However, despite l...
Guoliang Liu
Guoliang Liu
Avigail Baruch Leshem,Dor Gaash,Ayala Lampel
Avigail Baruch Leshem
Designed biomolecular condensates are emerging condensed-phase assemblies, initially conceived to mimic cellular biomolecular condensates for use in biology-inspired applications such as delivery and storage of biomolecules. In recent years...
An ultrasmall core-shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments [0.03%]
超小型核壳结构二氧化硅纳米颗粒通过重塑抑制性黑色素瘤微环境提高抗肿瘤免疫并改善生存率
Gabriel De Leon,Li Zhang,Nabil A Siddiqui et al.
Gabriel De Leon et al.
Despite the considerable success of clinically approved immune-based therapies for treating advanced melanoma, a significant fraction of patients are not responsive owing to mechanisms engaged by the tumour to evade the immune system. Here ...
Viral glycoprotein-mimicking peptide-functionalized micelles promote drug delivery to diseased chondrocytes for osteoarthritis alleviation [0.03%]
模拟病毒糖蛋白的肽修饰的米勒粒促进药物向骨关节炎病灶软骨细胞传递以缓解病情
Xiao Chen,Dongyang Zhou,Jian Wang et al.
Xiao Chen et al.
Osteoarthritis (OA) affects a large population worldwide, causing chronic pain, functional decline, and increased personal and societal medical costs. A major challenge in developing disease-modifying OA drugs (DMOADs) is the inefficient de...