VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients [0.03%]
C2578A多态性不是散发性中国ALS患者的易感因素
Yingshuang Zhang,Huagang Zhang,Yu Fu et al.
Yingshuang Zhang et al.
A linkage and association of the VEGF (vascular endothelial growth factor) C2578A polymorphism and amyotrophic lateral sclerosis (ALS) has been found in some studies. We analysed the C2578A polymorphism in sporadic ALS patients from a Chine...
Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes [0.03%]
快速准确的筛选ENU诱变小鼠异常运动表型的方法
Wanda Abramow-Newerly,Tatiana Lipina,Maria Abramow-Newerly et al.
Wanda Abramow-Newerly et al.
In a dominant genetic screen for late-onset motor impairments in mice, 16-20-week-old N-nitroso-N-ethylurea (ENU)-mutagenized females were subjected to a behavioural test battery consisting of a visual assessment followed by the vertical po...
A clinical pilot study: high frequency chest wall oscillation airway clearance in patients with amyotrophic lateral sclerosis [0.03%]
高频胸部震荡在肌萎缩侧索硬化症患者气道廓清中的临床研究
Kathleen Marya Chaisson,Susan Walsh,Zachary Simmons et al.
Kathleen Marya Chaisson et al.
Respiratory complications are common in patients with amyotrophic lateral sclerosis (ALS) with respiratory failure representing the most common cause of death. Ineffective airway clearance resultant from deficient cough frequently contribut...
A retrospective analysis of sleep quality and survival with domiciliary ventilatory support in motor neuron disease [0.03%]
延胡索酸酶神经元疾病居家通气支持患者的生存率和睡眠质量的回顾性分析
David J Berlowitz,Karen Detering,Linda Schachter
David J Berlowitz
Previous studies have demonstrated that domiciliary ventilatory support improves survival, quality of life and cognitive function in motor neuron disease (MND). These benefits are partly attributed to better sleep quality and less hypoxia. ...
Evaluation of sham non-invasive ventilation for randomized, controlled trials in ALS [0.03%]
ALS中随机对照试验的假非侵入性通气评估
Kirsten L Gruis,Devin L Brown,Kevin J Weatherwax et al.
Kirsten L Gruis et al.
Non-invasive positive pressure ventilation (NIV) treatment of advanced respiratory insufficiency prolongs survival in ALS. To investigate the critical question of whether earlier initiation of NIV might provide additional benefit, a randomi...
Predictors and course of elective long-term mechanical ventilation: A prospective study of ALS patients [0.03%]
选择性长期机械通气的预测因素及其在ALS患者中的应用效果：一项前瞻性研究
Judith G Rabkin,Steven M Albert,Toby Tider et al.
Judith G Rabkin et al.
We sought to characterize ALS patients who opt for tracheostomy and long-term mechanical ventilation (LTMV) and compare them with respect to medical, psychiatric, and psychosocial measures to patients who declined tracheostomy and died. We ...
Carlayne E Jackson,Steven Lovitt,Neelam Gowda et al.
Carlayne E Jackson et al.
In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were a...
A phenotypic-genetic study of a group of Polish patients with spinal and bulbar muscular atrophy [0.03%]
波兰脊髓性和球体肌肉萎缩症患者群的表型-基因型研究
Barbara Tomik,Dorota Partyka,Anna Sułek et al.
Barbara Tomik et al.
We studied phenotype-genotype correlation in a group of Polish males with spinal and bulbar muscular atrophy (SBMA) and in female carriers. Eleven males with suspected SBMA phenotype and three suspected female carriers were examined. Male p...
Audit of outcomes in motor neuron disease (MND) patients treated with riluzole [0.03%]
评估利鲁唑治疗肌萎缩侧索硬化患者的效果
J Douglas Mitchell,Mary R O&#x;brien,Miland Joshi
J Douglas Mitchell
A review of riluzole in MND by NICE concluded that riluzole was modestly effective. NICE however suggested that further studies were needed to gain further insights into its clinical effectiveness. As these studies have not been carried out...
A4V superoxide dismutase mutation in apparently sporadic ALS resembling neuralgic amyotrophy [0.03%]
散发性ALS患者中A4V型超氧化物歧化酶1基因突变与神经痛性肌萎缩综合征样表现有关
M D Weiss,J M Ravits,N Schuman et al.
M D Weiss et al.
We report a case of apparently sporadic amyotrophic lateral sclerosis (ALS) in a young pregnant woman presenting subacutely with severe left shoulder pain followed by progressive weakness and wasting of the left arm, mimicking neuralgic amy...