Trygve Holmøy,Per M Roos,Espen Østhagen Kvale
Trygve Holmøy
T -cells are present in the spinal cord from patients with amyotrophic lateral sclerosis (ALS), and could attack neurons or activate microglia through secretion of cytokines. We report that interferon (IFN)-gamma, tumour necrosis factor (TN...
Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS) [0.03%]
肌萎缩侧索硬化症（ALS）易感性和进展率的修饰因素分析
M Muddasir Qureshi,Douglas Hayden,Leo Urbinelli et al.
M Muddasir Qureshi et al.
We conducted case-control and prospective longitudinal studies to examine risk factors and predictors of disease progression for ALS. Ninety-five subjects with ALS and 106 healthy control subjects were enrolled. All subjects completed a ris...
Measurement of decline of functioning in persons with amyotrophic lateral sclerosis: responsiveness and possible applications of the Functional Independence Measure, Barthel Index, Rehabilitation Activities Profile and Frenchay Activities Index [0.03%]
肌萎缩侧索硬化症患者功能减退的测量：功能独立度量表、巴塞尔指数、康复活动谱和Frenchay 活动指数的反应性和可能应用
Imelda J M De Groot,Marcel W M Post,Tineke Van Heuveln et al.
Imelda J M De Groot et al.
It is important not only to monitor the functional change during the course of ALS, but also to determine whether or not the available help is sufficient. This study was performed to determine which generic assessment instrument is most app...
How does current care practice influence the experience of a new diagnosis of motor neuron disease? A qualitative study of current guidelines-based practice [0.03%]
当前诊疗实践如何影响新诊断运动神经元疾病患者的经历？基于现行指南的定性研究
Heino Hugel,Nicky Grundy,Sally Rigby et al.
Heino Hugel et al.
Management during the diagnostic phase of MND is considered an important influence on the patient's further disease course. Guidelines for the management of MND have been developed, but little is known on how recommended practices influence...
Ambre Piquard,Nadine Le Forestier,Véronique Baudoin-Madec et al.
Ambre Piquard et al.
Primary lateral sclerosis (PLS) has been defined as rare, and the neuropsychological changes remain poorly defined. We studied 20 patients with a diagnosis of PLS. We carried out an extensive psychometric testing including a general assessm...
Clinical phenotypes of a large Chinese multigenerational kindred with autosomal dominant familial ALS due to Ile149Thr SOD1 gene mutation [0.03%]
中国SOD1基因Ile149Thr突变常染色体显性遗传家族性肌萎缩侧索硬化的临床表型研究
Gardian C Y Fong,Ken H H Kwok,Y Q Song et al.
Gardian C Y Fong et al.
About 10% of amyotrophic lateral sclerosis (ALS) cases are familial. We identified a five-generation Chinese family with autosomal dominant familial ALS (FALS). We performed a detailed family study, clinical and electromyographic validation...
Carole Mockford,Crispin Jenkinson,Raymond Fitzpatrick
Carole Mockford
Carers of people with MND may experience changes to their health and lifestyle. Statutory and voluntary organizations are able to support the carer in various ways. This review investigates the personal impact on carers and their experience...
Ettore Beghi,Caterina Bendotti,Tiziana Mennini
Ettore Beghi
Eric J Sorenson
Eric J Sorenson
The genetics of the motor neuron diseases are becoming increasingly important. The relationship of primary lateral sclerosis and amyotrophic lateral sclerosis remains debated. Here a pair of monozygotic twins discordant for primary lateral ...