Gianni Sorarù,Elena Pegoraro,Paolo Spinella et al.
Gianni Sorarù et al.
Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study) [0.03%]
依达拉奉治疗肌萎缩侧索硬化症的疗效观察（二期临床研究）
Hiide Yoshino,Akio Kimura
Hiide Yoshino
Amyotrophic lateral sclerosis (ALS) is a rare disease involving selective and progressive degeneration and disappearance of motor neurons. Oxidative stress is believed to contribute to its pathogenesis. We have investigated the efficacy and...
Manofluorographic evaluation of swallowing in amyotrophic lateral sclerosis and its relationship with clinical evaluation of swallowing [0.03%]
ALS吞咽的电视透视评估及其与临床吞咽评估的关系研究
Ann Goeleven,Wim Robberecht,Barbara Sonies et al.
Ann Goeleven et al.
The aim of this cross-sectional study was, first, to identify swallowing dysfunctions in an ALS population of 40 consecutive patients through combined videofluoroscopy and manometry. Secondly, these objective swallowing data were correlated...
Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis [0.03%]
散发性肌萎缩侧索硬化症中FMO1基因单核苷酸多态性发生率增加
Cristina Cereda,Elisa Gabanti,Manuel Corato et al.
Cristina Cereda et al.
Flavin-containing monooxygenases (FMO) represent a gene family involved in the oxidative metabolism of a variety of xenobiotics, pesticides and drugs. A new function for FMO proteins has been recently uncovered: yeast FMO has been demonstra...
Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis [0.03%]
多个hNT细胞移植到SOD1基因ALS模型鼠脊髓内
Svitlana Garbuzova-Davis,Alison E Willing,Samuel Saporta et al.
Svitlana Garbuzova-Davis et al.
hNT cells, derived from a human teratocarcinoma cell line, are versatile neuron-like cells that have been studied as possible treatment vehicles for neurodegenerative diseases. Previously, we showed the postponement of motor deficit symptom...
Jessica Mandrioli,Pietro Faglioni,Paolo Nichelli et al.
Jessica Mandrioli et al.
Amyotrophic lateral sclerosis (ALS) has a fatal outcome in about three years, but survival is known to vary considerably, making it difficult to predict disease duration in individual cases. The aim of this study was to investigate possible...
Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex [0.03%]
基因表达谱分析揭示渐冻症患者大脑皮层中的差异表达基因
Xin-Sheng Wang,Zachary Simmons,Wenlei Liu et al.
Xin-Sheng Wang et al.
The possible causes of ALS are unknown and multiple biological systems have been implicated. The goal of this study was to use gene expression profiling to evaluate a broad spectrum of systems in ALS. For this study, the medial lip of the h...
Effect of non-invasive ventilation on survival, quality of life, respiratory function and cognition: a review of the literature [0.03%]
无创通气对生存、生活质量、肺功能及认知的影响：文献综述
Sanne Piepers,Jan-Paul van den Berg,Sandra Kalmijn et al.
Sanne Piepers et al.
Symptoms of nocturnal hypoventilation may negatively influence the quality of life (QoL) of ALS patients long before respiratory failure ensues. Non-invasive mechanical ventilation (NIV) is considered a treatment option for nocturnal hypove...
Alexis Descatha,Sybille Goddet,Jérome Aboab et al.
Alexis Descatha et al.