Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial [0.03%]
一项多中心临床试验中ALSFRS-R的优良评分者间、评分者内及电话评估信度
Petra Kaufmann,Gilbero Levy,Jacquelina Montes et al.
Petra Kaufmann et al.
We wished to determine whether the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) is reliable when used as primary outcome measure in a multicenter clinical trial. To establish inter-rater reliability, we randomly ...
Respiratory systems abnormalities and clinical milestones for patients with amyotrophic lateral sclerosis with emphasis upon survival [0.03%]
以生存期为重点的肌萎缩侧索硬化患者的呼吸系统异常和临床特征分析
Robert L Vender,David Mauger,Susan Walsh et al.
Robert L Vender et al.
Respiratory system complications and abnormalities are common in patients with amyotrophic lateral sclerosis (ALS) and respiratory failure remains the most common cause of death. Extensive epidemiological longitudinal data have documented t...
Erythropoietin does not preserve motor neurons in a mouse model of familial ALS [0.03%]
人源红细胞生成素不能延缓鼠模型渐冻症的运动神经元病变过程
Giuliano Grignaschi,Eleonora Zennaro,Massimo Tortarolo et al.
Giuliano Grignaschi et al.
Recombinant human EPO (r-Hu-EPO) protects cultured motor neurons from kainate- and serum deprivation-induced toxicity and readily enters the CNS after systemic injection. We examined the effect of rHuEPO in transgenic mice expressing the hu...
Are enteroviral receptors different in sporadic motor neuron disease? [0.03%]
脊髓性肌肉萎缩症患者中进入病毒受体是否存在差异？
Rebecca B Saunderson,Bing Yu,Ronald J A Trent et al.
Rebecca B Saunderson et al.
Enteroviruses have been suspected to play a part in the pathogenesis of sporadic motor neuron disease (SMND). Intercellular adhesion molecule type-1 (ICAM1) and coxsackie and adenovirus receptor (CAR) act as receptors for a number of entero...
Sexual dimorphism in disease onset and progression of a rat model of ALS [0.03%]
ALS疾病模型中疾病的发病和发展的性别二态性研究
Masatoshi Suzuki,Craig Tork,Brandon Shelley et al.
Masatoshi Suzuki et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing the progressive loss of brain and spinal cord motor neurons. The exact etiology of ALS is still uncertain, but males have consistently been shown to be at a hi...
Measuring the cortical silent period can increase diagnostic confidence for amyotrophic lateral sclerosis [0.03%]
测量皮质静息期可以增加肌萎缩侧索硬化诊断信心
H Jurgen Schelhaas,Ilse M Arts,Sebastiaan Overeem et al.
H Jurgen Schelhaas et al.
We evaluated a modified measurement of the cortical silent period (CSP) as a simple procedure to add further confidence in the diagnostic work-up for ALS. Thirty-seven consecutive patients with a suspicion of having ALS were included togeth...
Brain perfusion imaging in amyotrophic lateral sclerosis: extent of cortical changes according to the severity and topography of motor impairment [0.03%]
渐冻症患者的脑灌注显像：根据运动障碍的程度和部位反映皮层改变的范围
Marie-Odile Habert,Lucette Lacomblez,Philippe Maksud et al.
Marie-Odile Habert et al.
In amyotrophic lateral sclerosis (ALS), attempts have been made to correlate the extent of cortical lesions with the intensity of motor dysfunction in ALS patients. Our aim was to compare the cerebral perfusion as measured by SPECT with the...
A prospective study to evaluate the impact of 31P-MRS to determinate mitochondrial dysfunction in skeletal muscle of ALS patients [0.03%]
前瞻性研究评估31P磁共振光谱测定肌萎缩侧索硬化患者骨骼肌线粒体功能障碍的影响
Torsten Grehl,Stephan Fischer,Klaus Müller et al.
Torsten Grehl et al.
Impaired mitochondrial energy production probably plays a role in motor neuron death in amyotrophic lateral sclerosis (ALS) and has been found not only in motor neurons but also in skeletal muscle of patients with ALS. 31P magnetic resonanc...
Petra Kaufmann,Hiroshi Mitsumoto;ALSRG Database Task Force Steering Committee;ALSRG Members;ALS Research Group
Petra Kaufmann
Clinical highlights [0.03%]
临床亮点
Gian Domenico Borasio;Symposium on ALS/MND
Gian Domenico Borasio;Symposium on ALS/MND