Validity of the Dutch version of the Amyotrophic Lateral Sclerosis Assessment Questionnaire, ALSAQ-40, ALSAQ-5 [0.03%]
荷兰语版渐冻症评估问卷（ALSAQ-40，ALSAQ-5）的有效性研究
Maud Maessen,Marcel W Post,Rianne Maillé et al.
Maud Maessen et al.
The objective was to validate the Dutch translation of the 40-item and 5-item Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40, ALSAQ-5). Eighty-one ALS patients participated in this cross-sectional study. The measures used ...
The Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40): evidence for a method of imputing missing data [0.03%]
阿尔茨海默病评估问卷（ALSAQ-40）：填补缺失数据的方法的有效性证据
Crispin Jenkinson,Robert Harris,Ray Fitzpatrick
Crispin Jenkinson
The Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40) is the most widely validated measure of health status for use with patients diagnosed with motor neuron disease/amyotrophic lateral sclerosis (MND/ALS). The questionnaire...
Incidence of aspiration pneumonia in ALS in Olmsted County, MN [0.03%]
美国明尼苏达州奥姆斯特德县ALS患者吸入性肺炎的发病率研究
Eric J Sorenson,Brian Crum,J Clarke Stevens
Eric J Sorenson
Aspiration pneumonia is believed to be an uncommon complication of amyotrophic lateral sclerosis (ALS). However, the incidence of aspiration pneumonia and its contribution to morbidity and mortality are unknown in ALS. All cases of ALS from...
Nathan Oates,Roger Pamphlett
Nathan Oates
Epigenetic silencing of a gene vital for motor neuron function could underlie sporadic ALS. We therefore examined the methylation status of two genes, SOD1 and VEGF, which are implicated in ALS. Methylation in the promoters of these genes w...
Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord [0.03%]
ALS患者脑脊液致新生大鼠脊髓高尔基体解体
Priti Y Ramamohan,M Gourie-Devi,A Nalini et al.
Priti Y Ramamohan et al.
We have previously shown in our laboratory that cerebrospinal fluid from ALS patients (ALS-CSF) contains putative toxic factor(s). In the present study we determined the effect of ALS-CSF on the integrity of the Golgi apparatus of spinal mo...
Clinical characteristics of familial amyotrophic lateral sclerosis with a Phe20Cys mutation in the SOD1 gene in a Korean family [0.03%]
SOD1基因Phe20Cys突变韩国家族性肌萎缩侧索硬化的临床特征
Hyun Young Kim,Chang-Seok Ki,Seong-Ho Koh et al.
Hyun Young Kim et al.
Familial ALS (FALS) is mostly inherited as an age-dependent autosomal dominant trait. Since the discovery of mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), testing for SOD1 gene mutations has become a routine part of the ...
Elevated levels of transcripts encoding a human retroviral envelope protein (syncytin) in muscles from patients with motor neuron disease [0.03%]
运动神经元病患者肌肉中携有人类反转录病毒包膜蛋白（合胞素）编码转录本水平升高
Steven O A Oluwole,Yuanrong Yao,Sebastian Conradi et al.
Steven O A Oluwole et al.
Retroviral components of both exogenous and endogenous origins have been associated with nervous system diseases in both animals and humans. In the present study, the levels of transcripts from elements in the human endogenous retrovirus (H...
Eric J Sorenson,Christopher J Klein
Eric J Sorenson
X-linked spinal and bulbar muscular atrophy (SBMA or Kennedy's disease) has a variable prognosis. Most male carriers are affected by their fourth or fifth decade of life, while some remain asymptomatic lifelong. Elevations of serum creatine...
Alison B Grossman,Susan Woolley-Levine,Walter G Bradley et al.
Alison B Grossman et al.
Cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is well documented, but behavioral abnormalities are not well defined. The Frontal Systems Behavior Scale (FrSBe) was used to assess changes in apathy, disinhibition,...
Maximum voluntary isometric contraction: reference values and clinical application [0.03%]
最大自主等长收缩：参考值及临床应用
Dara Meldrum,Eibhlis Cahalane,Ronan Conroy et al.
Dara Meldrum et al.
Maximum voluntary isometric contraction (MVIC) is a standardized method for measurement of muscle strength in patients with neuromuscular disease. Values obtained from MVIC testing are difficult to interpret at present as normative data are...