Elisabeth Sadot,Laurence Carluer,Philippe Corcia et al.
Elisabeth Sadot et al.
We report seven women, aged 52-78 years, with motor neuron disease (MND) associated with breast cancer. In five, cancer preceded MND by 30 years to 24 months, while in the remaining two it occurred from 8.5 years to one month after MND onse...
RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis [0.03%]
渐冻症患者血清和脑脊液中RANTES水平升高
Michael Rentzos,Chryssoula Nikolaou,Antonis Rombos et al.
Michael Rentzos et al.
Immunological disturbances have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Chemokines are involved in the recruitment of immune cells. Regulated upon activation, normal T-cell expressed and secreted (RANTES)...
Jacqueline Montes,Bin Cheng,Beverly Diamond et al.
Jacqueline Montes et al.
There are few functionally meaningful clinical measures used to guide management of patients with ALS. Falls are common, can be debilitating, and result in increased health care costs. We assessed the performance and ability to predict fall...
Clinical patterns in progressive muscular atrophy (PMA): a prospective study [0.03%]
进行性肌萎缩(PMA)的临床分型研究
Mamede de Carvalho,Manuel Scotto,Michael Swash
Mamede de Carvalho
Progressive muscular atrophy (PMA) is a form of motor neuron disease, but its outcome is not well defined, and the aim was to study the pattern of clinical progression in PMA. We studied 10 patients prospectively for 12 months. None showed ...
Nutritional status and risk of amyotrophic lateral sclerosis in Japan [0.03%]
日本营养状况与肌萎缩侧索硬化症风险的关系研究
Kazushi Okamoto,Tameko Kihira,Tomoyoshi Kondo et al.
Kazushi Okamoto et al.
Only a few human studies have reported the relationship between dietary factors and the risk of amyotrophic lateral sclerosis (ALS). We therefore analyzed the relationship between macronutrients (carbohydrate, protein and fat) and the risk ...
Alyssa J Averill,Edward J Kasarskis,Suzanne C Segerstrom
Alyssa J Averill
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with no known effective treatment or cure. Clinicians often expect that ALS patients will experience depression following the diagnosis because ALS is ...
Glatiramer acetate immunization induces specific antibody and cytokine responses in ALS patients [0.03%]
乙酰佐米茋胺免疫诱导ALS患者产生特异性抗体和细胞因子反应
R Lee Mosley,Paul H Gordon,Christopher M Hasiak et al.
R Lee Mosley et al.
We assessed humoral and cytokine responses in monthly plasma samples from ALS patients who received glatiramer acetate (GA) immunization every day or every other week, or remained untreated (control) from a six-month phase II trial. Samples...
Yansu Guo,Yaling Liu,Lei Xu et al.
Yansu Guo et al.
Reactive astrogliosis has been found in the cerebral cortex and spinal cord in amyotrophic lateral sclerosis, whereas astrocytic pathology in immune-mediated motor neuron injury has not been reported. On the basis of the establishment of an...
Disease progression and survival in ALS: first multi-state model approach [0.03%]
ALS疾病进展和生存的多状态模型方法研究
Juan Gil,Pierre-Marie Preux,Ahmadou Alioum et al.
Juan Gil et al.
Although several prognostic factors have been identified in ALS, there remains some discordance concerning the prognostic significance of the age and clinical form at onset. In order to clarify these findings, we have analysed already known...
Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop [0.03%]
ALS/MND药物的药理活性评估的前期临床体内评价指南：ENMC国际研讨会第142次会议报告
Albert C Ludolph,Caterina Bendotti,Eran Blaugrund et al.
Albert C Ludolph et al.
A transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu/Zn SOD mutations into the intact mouse genome. It serves to establish hypo...