Evidence for central abnormality in respiratory control in primary lateral sclerosis [0.03%]
原发性侧索硬化中呼吸控制中枢异常的证据
Raquel Gil Gouveia,Anabela Pinto,Teresinha Evangelista et al.
Raquel Gil Gouveia et al.
Primary lateral sclerosis (PLS) is a very rare disease characterized by pure upper motor neuron findings. Although a number of previous reports have evaluated this condition, no study has addressed the respiratory function in PLS. Six patie...
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach [0.03%]
采用标记单核苷酸多态性方法研究DYNC1H1基因与北欧血统散发性ALS病例对照之间的关联
Paresh R Shah,Azlina Ahmad-Annuar,Kourosh R Ahmadi et al.
Paresh R Shah et al.
The cytoplasmic dynein-dynactin complex has been implicated in the aetiology of motor neuron degeneration in both mouse models and human forms of motor neuron disease. We have previously shown that mutations in the cytoplasmic dynein 1 heav...
Nationwide survey of juvenile muscular atrophy of distal upper extremity (Hirayama disease) in Japan [0.03%]
日本 Hirayama 病(远端上肢肌萎缩)的全国调查
Kunio Tashiro,Seiji Kikuchi,Yasuo Itoyama et al.
Kunio Tashiro et al.
Juvenile muscular atrophy of the distal upper extremity (JMADUE, Hirayama disease) was first reported in 1959 as 'juvenile muscular atrophy of unilateral upper extremity'. Since then, similar patients in their teens or 20s have been describ...
Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis [0.03%]
天那普丁和吗啡在家族性肌萎缩侧索硬化转基因模型中的疗效
Muriel Chritin,Marc Savasta,Gerard Besson
Muriel Chritin
The familial form of amyotrophic lateral sclerosis (FALS) has been linked in some cases to dominant mutations in the gene encoding the Cu/Zn superoxide dismutase (SOD1) mutation. Transgenic mice bearing the G93A SOD1 mutation develop clinic...
Alison B Grossman,Bonnie E Levin,Walter G Bradley
Alison B Grossman
Experienced neurologists caring for patients with amyotrophic lateral sclerosis (ALS) have commented that these patients commonly exhibit similar personality features. Previous research studies on the premorbid personality characteristics o...
Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population [0.03%]
金属硫蛋白基因多态性与日本人散发性肌萎缩侧索硬化的关系
Yuichi Hayashi,Tatsuma Hashizume,Kenji Wakida et al.
Yuichi Hayashi et al.
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease that selectively affects motor neurons. Reactive oxygen species (ROS) are assumed to be involved in the pathogenesis of ALS. Metallothioneins (MTs) are s...
Survival of patients with ALS following institution of enteral feeding is related to pre-procedure oximetry: a retrospective review of 98 patients in a single centre [0.03%]
经回顾性分析单中心98例ALS患者的肠内营养前血氧饱和度与其生存期的关系研究
Ashley S Shaw,Mary-Ann Ampong,Alan Rio et al.
Ashley S Shaw et al.
A retrospective review was carried out on the influence of pre-procedure respiratory assessment on survival of patients with amyotrophic lateral sclerosis (ALS) requiring nutritional support with either a gastrostomy or a nasogastric feedin...
Management of respiration in MND/ALS patients: an evidence based review [0.03%]
基于证据的肌萎缩侧索硬化症患者呼吸管理综述
Catherine Heffernan,Crispin Jenkinson,Tricia Holmes et al.
Catherine Heffernan et al.
This systematic review comprises an objective appraisal of the evidence in regard to the management of respiration in patients with motor neuron disease (MND/ALS). Studies were identified through computerised searches of 32 databases. Inter...
Ventilation in ALS [0.03%]
ALS的通气护理
Mamede de Carvalho,Anabela Pinto
Mamede de Carvalho