When Hypereosinophilia occurs during dupilumab therapy: evidence-based strategies for clinical management in respiratory indications [0.03%]
Dupixent治疗期间发生嗜酸性粒细胞增多的应对措施：呼吸系统疾病中的临床管理策略证据探讨
Marco Caminati,Andrea Portacci,Francesca Cefaloni et al.
Marco Caminati et al.
Introduction: Dupilumab is a monoclonal antibody which selectively targets T2 inflammation by binding the IL-4 and 13 receptor and blocking its contribution to the immune activation. Clinical trials and real-life studies ...
Traditional biomarkers and clinical hallmarks in the frame of epithelial driven airways inflammation [0.03%]
从上皮驱动的气道炎症角度观察传统生物标志物和临床特征
Marco Caminati,Marco Zurlo,Giuseppe Guida et al.
Marco Caminati et al.
Introduction: The airway epithelium is composed of different cell types and acts as a physical barrier preventing pathogens, allergens and microbes from entering the lungs. The recent investigations on epithelial barrier ...
Respiratory syncytial virus immunoprophylaxis: an underutilized preventive strategy in children with Down syndrome [0.03%]
Down综合征儿童呼吸道合胞病毒免疫预防策略的应用不足
Lin Ammar,Rees Lee,Christian Rosas-Salazar et al.
Lin Ammar et al.
Introduction: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI) in young children, causing significant morbidity and mortality worldwide. Early life RSV LRTI adversely impact...
The role of the right ventricle in pulmonary arterial hypertension and imaging methods for non-invasive evaluation [0.03%]
右心室在肺动脉高压中的作用及无创评价肺动脉高压的影像学方法
Tatiana Kiyota,Paulo Mendes,Monica Corso Pereira
Tatiana Kiyota
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by the remodeling of pulmonary arterial circulation, leading to increased pulmonary vascular resistance (PVR) and right ventricula...
Understanding the relationship between eosinophils and chronic obstructive pulmonary disease. A new dawn? [0.03%]
eosinophil与慢性阻塞性肺疾病关系研究：新的希望？
Clare Tiedeman,Ian Pavord
Clare Tiedeman
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality. It is a complex and heterogeneous condition defined by the presence of incompletely reversible airflow obstr...
Small RNA-based formulations in precision cut lung slices - is there an alternative for in vivo/in vitro studies? [0.03%]
基于小型RNA的配方在精密切割肺片中的应用——体内/体外研究的替代方案吗？
Joanna Nowakowska-Lewicka,Aleksandra Szczepankiewicz
Joanna Nowakowska-Lewicka
Introduction: Precision cut lung slices (PCLS) are ex vivo models to study lung diseases. They have numerous advantages related to the presence of different cell types and extracellular matrix. They are an excellent platf...
Daniela Muti,Plamena Novakova,Silviya Novakova et al.
Daniela Muti et al.
Introduction: Severe asthma (SA) is a heterogenous disease with multiple clinical phenotypes. 'Early atopic asthma' is the predominant phenotype in children with SA. This phenotype is also identified in adults with SA. Ho...
Brittany Duchene,Anne E Dixon
Brittany Duchene
Introduction: Both asthma and depression are common diseases that significantly contribute to morbidity and mortality worldwide. Area covered: ...
The current evidence regarding the efficacy of tezepelumab administered for asthma on T2-related comorbidities [0.03%]
关于泰泽佩芦单抗治疗哮喘对2型相关并发症有效性的现有证据
Angelica Tiotiu
Angelica Tiotiu
Introduction: T2-comorbidities are the most common in severe asthma (SA) patients and have a negative impact on disease outcomes but also an important socio-economic burden. Treating SA and its comorbidities by one medica...
Malvika Bhatnagar,Rebecca Burney,Eihab O Bedawi
Malvika Bhatnagar
Introduction: Pleural infection is a common condition associated with significant morbidity, mortality, and prolonged hospital stay. Whilst antibiotics and chest tube drainage comprise initial management, over one-third o...