Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis? [0.03%]
特发性肺纤维化个性医学的目标能实现吗？
Victor J Thannickal,Veena B Antony
Victor J Thannickal
Anupam Kumar,Siddhartha G Kapnadak,Reda E Girgis et al.
Anupam Kumar et al.
Idiopathic Pulmonary Fibrosis (IPF) is a unique type of interstitial pneumonia in which progressive fibrosis can ultimately result in respiratory failure and death. The median survival of IPF remains dismal despite newer anti-fibrotic thera...
Inhalation therapy for repairing damaged elastin fibers and decelerating elastinolysis in chronic obstructive pulmonary disease [0.03%]
吸入疗法修复慢性阻塞性肺疾病受损的弹力纤维并减缓其降解
Rob Janssen,Ianthe Piscaer,Emiel Fm Wouters
Rob Janssen
Current pharmacologic therapy of chronic obstructive pulmonary disease (COPD) can reduce respiratory symptoms and exacerbation frequency. However, no single COPD intervention except for lung transplantation has proven effective in recoverin...
Current and future molecular approaches in the diagnosis of cystic fibrosis [0.03%]
囊性纤维化诊断的当前和未来的分子方法
Anne Bergougnoux,Magali Taulan-Cadars,Mireille Claustres et al.
Anne Bergougnoux et al.
Cystic Fibrosis is among the first diseases to have general population genetic screening tests and one of the most common indications of prenatal and preimplantation genetic diagnosis for single gene disorders. During the past twenty years,...
Amir A Zeki,Mona Elbadawi-Sidhu
Amir A Zeki
Asthma manifests as chronic airflow obstruction with persistent inflammation and airway hyperresponsiveness. The immunomodulatory and anti-inflammatory properties of the HMG-CoA reductase (HMGCR) inhibitors (a.k.a. statins), suggest a thera...
Ventilator-induced lung injury during controlled ventilation in patients with acute respiratory distress syndrome: less is probably better [0.03%]
急性呼吸窘迫综合征控制通气中机械通气所致肺损伤：少一点可能更好
Fernanda Ferreira Cruz,Lorenzo Ball,Patricia Rieken Macedo Rocco et al.
Fernanda Ferreira Cruz et al.
Mechanical ventilation is required to support respiratory function in the acute respiratory distress syndrome (ARDS), but it may promote lung damage, a phenomenon known as ventilator-induced lung injury (VILI). Areas covered: Several mechan...
Blood biomarkers in chronic airways diseases and their role in diagnosis and management [0.03%]
慢性气道疾病中的血液生物标志物及其在诊断和管理中的作用
Job J M H van Bragt,Susanne J H Vijverberg,Els J M Weersink et al.
Job J M H van Bragt et al.
The complexity and heterogeneous nature of asthma and chronic obstructive pulmonary disease (COPD) results in difficulties in diagnosing and treating patients. Biomarkers that can identify underlying mechanisms, identify patient phenotypes ...
Octavio Ramos-Espinosa,León Islas-Weinstein,Marco Polo Peralta-Álvarez et al.
Octavio Ramos-Espinosa et al.
Tuberculosis (TB) is the first cause of mortality by a single infectious agent in the world, causing more than one million deaths worldwide as reported by the World Health Organization (WHO). For the optimal control of TB infection, a prote...
Non-vitamin K antagonist oral anticoagulants for pulmonary embolism: who, where and for how long? [0.03%]
肺血栓栓塞症口服非维生素K拮抗剂类抗凝药：用给谁？用在哪？用多久？
Luke S Howard
Luke S Howard
Acute pulmonary embolism (PE) is a relatively common cardiopulmonary emergency that is a major cause of hospitalization and morbidity and is the primary cause of mortality associated with venous thromboembolism (VTE). During the last decade...
Jean-François Etter
Jean-François Etter