JUNB transcriptional regulation of KRT20 via ITGB1 activates PI3K/AKT signaling pathway against fibrosis-induced by renal injury [0.03%]
ITGB1介导的JUNB/KRT20轴活化PI3K/AKT信号通路抵抗肾损伤后纤维化
Haonan Mei,Xinmiao Ni,Qingyuan Zheng et al.
Haonan Mei et al.
ALDH2 inhibits FASN stabilization via the E3 ligase CBL to suppress lipid accumulation and liver cancer development [0.03%]
醛脱氢酶2通过E3泛素连接酶CBL抑制脂肪酸合成酶的稳定以抑制脂质积累和肝癌发生
Yuxin Wang,Lu Li,Fanqi Qu et al.
Yuxin Wang et al.
Qichen Huang,Junyu Ke,Xinrui Shen et al.
Qichen Huang et al.
A cyclin D1-CDK4/6-E2F dependency represents an acquired vulnerability in cisplatin-resistant bladder cancer [0.03%]
一种cyclin D1-CDK4/6-E2F依赖性代表了顺铂耐药膀胱癌中的获得性弱点
Tsung-Han Hsieh,Han-Pin Kuo,Chun-Hsu Pan et al.
Tsung-Han Hsieh et al.
SH3BGRL3 promotes radioresistance and immune evasion in triple-negative breast cancer by regulating Rab27a [0.03%]
SH3BGRL3通过调节Rab27a促进三阴性乳腺癌的放疗抗性和免疫逃逸
Li Wang,Fei Lu,Jingyan Gao et al.
Li Wang et al.
Transcription factor IRF1 modulates HDAC1 and PANoptosis to regulate preeclampsia progression [0.03%]
转录因子IRF1通过调节HDAC1和PANoptosis调控子痫前期的发展
Zhichao Wang,Long Cheng,Guanghui Li et al.
Zhichao Wang et al.
Background: Preeclampsia (PE) is a pregnancy-specific disorder posing significant maternal-fetal risks, while interferon regulatory factor 1 (IRF1) is a transcriptional regulator associated with inflammatory responses. In...
Impeding hypoxia-driven tumor progression in hepatocellular carcinoma: clinical and pre-clinical analyses using 2D and 3D in vitro models [0.03%]
利用二维和三维体外模型阻碍肝细胞癌中缺氧驱动的肿瘤进展：临床和基础实验分析
Tania Payo-Serafín,Carolina Méndez-Blanco,Jennifer Martínez-Geijo et al.
Tania Payo-Serafín et al.
Background: Hypoxia is a hallmark of the hepatocellular carcinoma (HCC) microenvironment, promoting tumor progression, therapy resistance, and poor prognosis. Central mediators of the hypoxic response are the hypoxia-indu...
A hybrid ST-ViT-driven multimodal architecture combining spatiotemporal MRI patterns and radiomic features for enhanced prediction of pCR in neoadjuvant breast cancer therapy [0.03%]
结合时空MRI模式和影像组学特征的混合ST-ViT驱动多模态架构，以增强新辅助乳腺癌治疗中pCR的预测能力
Satyabrata Pattanayak,Tripty Singh,Rishabh Kumar et al.
Satyabrata Pattanayak et al.
Single-cell analysis highlights the role of CD4+ IFN-I-related T cells in Behcet's uveitis during Interferonα-2a therapy [0.03%]
单细胞测序揭示CD4+IFN-I相关T细胞在干扰素诱导的Behcet氏病性葡萄膜炎中的作用
Meiqi Wang,Deyu Zhang,Xue Huang et al.
Meiqi Wang et al.
Background: Behcet's disease (BD) involves multiple immune cells, but the mechanism by which interferon α-2a (IFNα-2a) exerts therapeutic effects on BD through immune cell modulation remains unclear. This study aimed to...
Toxicological effects of acrylamide on oocyte maturation and subsequent embryonic development in a porcine model [0.03%]
丙烯酰胺对猪卵母细胞体外成熟及胚胎早期发育的影响研究
Na-Gyeom Oh,Pil-Soo Jeong,Hyo-Gu Kang et al.
Na-Gyeom Oh et al.