Protective effect of Caftaric Acid against hepatic cold ischemia/reperfusion injury in the liver [0.03%]
氯ogenic酸对肝脏冷缺血/再灌注损伤的保护作用
Ying Zhu,Hao Li,Minghao Li et al.
Ying Zhu et al.
Hepatic cold ischemia/reperfusion (I/R) injury persists during the perioperative period of liver transplantation (LT), exerting a profound impact on graft survival and being closely associated with the occurrence of early allograft dysfunct...
BCL6B suppresses acute myeloid leukemia progression by transcriptionally repressing GGT5 and modulating MAPK signaling [0.03%]
BCL6B通过转录抑制GGT5并调节MAPK信号传导来抑制急性髓系白血病进展
Yuqing Pan,Kun Wu,Xiaobo Ma et al.
Yuqing Pan et al.
Background: BCL6B has been implicated as a tumor suppressor in several solid malignancies; however, its biological function and molecular mechanisms in acute myeloid leukemia (AML) remain insufficiently defined. ...
ETV4 promotes colorectal cancer progression through SLC7A11-mediated ferroptosis inhibition [0.03%]
ETV4通过SLC7A11介导的铁死亡抑制促进结直肠癌进展
Zhouzhou Chao,Jinbao Yin,Fengxia Huang et al.
Zhouzhou Chao et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally. Ferroptosis, a regulated form of cell death, has emerged as a promising frontier in CRC treatment. The transcriptional regu...
Discovering non-linear dynamics of miRNAs in Alzheimer's disease-related cognitive impairment: a cross-species approach with explainable machine learning [0.03%]
基于可解释机器学习的跨物种方法发现阿尔茨海默病相关认知障碍中miRNA的非线性动力学规律
Seong-Hun Lee,Shin Kim,Seung-Bo Lee
Seong-Hun Lee
Background: MicroRNA (miRNA) biomarker studies in Alzheimer's disease (AD) typically assume monotonic relationships between expression levels and disease status, overlooking the non-linear, context-dependent nature of miR...
The role of autophagy in ocular health: mechanisms, pathologies, and therapeutic strategies [0.03%]
自噬在眼部健康中的作用：机制、病理和治疗策略
Mingyu Huang,Yumeng Lin,Hong Zhang et al.
Mingyu Huang et al.
Autophagy is a self-digestive process in which cellular components are degraded and recycled to maintain homeostasis and cope with stress. When cells are in a state of stress, autophagy will degrade proteins, lipids and damaged organelles, ...
Tetrahydropalmatine may alleviate doxorubicin-induced renal injury by activating the Sirt3-mediated Nrf2/HO-1 pathway [0.03%]
四氢帕马丁通过激活Sirt3介导的Nrf2/HO-1信号通路缓解阿霉素诱导的肾损伤
Wei Wang,Yuanyuan Hu,Yan Xu et al.
Wei Wang et al.
PPBP orchestrates autophagy-apoptosis imbalance to drive cartilage degeneration in osteoarthritis [0.03%]
PPBP通过调节自噬-凋亡失衡驱动骨关节炎软骨退变
Han Zhang,Kehao Hou,Xiao Ma et al.
Han Zhang et al.
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage destruction, in which dysregulated chondrocyte apoptosis and impaired autophagy play critical roles, yet the upstream molecular drivers rem...
Carbomol hydrogels integrating chlorogenic acid-loaded exosomes promote diabetic wound healing through antibacterial and immunomodulatory activities [0.03%]
基于载绿原酸的外泌体碳复合水凝胶通过抗菌和免疫调节活性促进糖尿病创面修复
Hehui Wang,Ming Guan,Guangyu Chu et al.
Hehui Wang et al.
Diabetic wounds represent a significant global clinical challenge, exacerbated by persistent bacterial infection and a dysregulated inflammatory microenvironment. Effective strategies for diabetic wounds are absent. Here, we found that NOD-...
HucMSC-derived exosomes alleviate inflammatory bowel disease via upregulating FXR to suppress macrophage ferroptosis [0.03%]
人源UC-MSC衍生的外泌体通过上调FXR抑制巨噬细胞铁死亡从而缓解IBD研究
Yuxuan Xia,Ting Sun,Mengjiao Zhou et al.
Yuxuan Xia et al.
Inflammatory bowel disease (IBD) is a chronic intestinal disorder characterized by excessive inflammation and intestinal damage. Known for its chronic and relapsing nature, IBD currently lacks curative pharmacological therapies. Herein, we ...
Integrative transcriptomic profiling reveals NK cell exhaustion-associated prognostic genes and identifies CSF1 as a key immunoregulatory target in hepatocellular carcinoma [0.03%]
整合转录组分析揭示NK细胞耗竭相关预后基因并鉴定出CSF1是肝癌免疫调节关键靶点
Yu Wang,Xiaoyan Xu,Yu Qi et al.
Yu Wang et al.
Background: Hepatocellular carcinoma (HCC) features a complex tumor immune microenvironment (TIME) where natural killer cell exhaustion (NKEX) facilitates immune evasion. Its regulatory networks and prognostic value remai...