Elevated NDUFAF2 expression correlates with poor prognosis and drives metabolic dependency in hepatocellular carcinoma [0.03%]
NDUFAF2高表达与肝癌预后不良及代谢依赖相关
Peiting Zeng,Jingshu Wang,Wenhua Lu et al.
Peiting Zeng et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic options for advanced and immunotherapy-resistant cases. Mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a...
Dysregulated competitive splicing between circular and linear RNAs characterizes hepatocellular carcinoma tumorigenesis and recurrence [0.03%]
竞争性拼接调控异常介导了肝癌发生发展及术后复发
Sunlu Jiang,Ning Cui,Lei Nie et al.
Sunlu Jiang et al.
Hepatocellular carcinoma (HCC) remains a global health challenge with a high recurrence rate, highlighting the need to decipher its underlying molecular mechanisms. While circular RNAs (circRNAs) are known to regulate gene expression, the l...
MYC promotes myocardial fibrosis via METTL1-mediated m7G modification of HILPDA [0.03%]
METTL1介导的HILPDAm7G修饰介导的MYC促进心肌纤维化
Yue Liu,Kai Li,Yi Chen et al.
Yue Liu et al.
Background: Post-infarction myocardial fibrosis is a pivotal pathological process leading to heart failure; however, its epitranscriptional regulatory mechanisms remain poorly defined. The role of the MYC-METTL1-HILPDA ax...
Harnessing meta-analysis and artificial intelligence to reveal conserved regulatory biosignatures of abiotic stress in soybean [0.03%]
利用Meta分析和人工智能揭示大豆非生物胁迫保守调节生物标志物
Parbej Laskar,Brijendra Singh
Parbej Laskar
Background: Soybeans are widely cultivated worldwide as an important source of edible vegetable oil and protein. Due to climate change, it is repeatedly exposed to various abiotic stressors in its natural habitat. Abiotic...
Cancer-associated fibroblasts-derived exosomal circ_0067557 promotes colorectal cancer epithelial-mesenchymal transition via BHLHE40-mediated transcriptional activation of OTUB2 [0.03%]
癌相关成纤维细胞来源的环状RNA circ_0067557通过BHLHE40介导的转录激活OTUB2促进结直肠癌上皮间质转化
Daoxu Zhang,Jiaqi Zhang,Cheng Yang et al.
Daoxu Zhang et al.
Objective: This study aimed to clarify how cancer-associated fibroblast-derived exosomal circ_0067557 (CAF-exo circ_0067557) promotes epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) through BHLHE40-medi...
Integrative satellitomics reveals distinct patterns of organization, transcription and evolution of satellite DNAs in Tenebrio molitor [0.03%]
整合卫星DNA组学揭示了米蛾卫星DNA的组织、转录和进化中的不同模式
Patrik Majcen,Antonio Sermek,Đurđica Ugarković et al.
Patrik Majcen et al.
Satellite DNAs (satDNAs) are repetitive sequences that play important roles in chromosomal architecture, genome evolution, and regulation. Here, we present a comprehensive characterization of Tenebrio molitor satellitome, integrating cytoge...
ELOVL1 promotes the progression of intrahepatic cholangiocarcinoma by enhancing endoplasmic reticulum stress and the PI3K/AKT/mTOR signaling pathway [0.03%]
ELOVL1通过增强内质网应激和PI3K/AKT/mTOR信号通路促进肝内胆管癌的发展
Weigen Wu,Danhong Zhan,Yihui Gao et al.
Weigen Wu et al.
Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive liver malignancy characterized by an adverse outcome attributed to delayed detection, elevated recurrence rates, and resistance to chemotherapy. Id...
A pyroptosis-related molecular signature stratifies prognosis and highlights GSDMB-mediated malignancy in intrahepatic cholangiocarcinoma [0.03%]
与焦亡相关的分子特征对肝内胆管癌预后的分层以及GSDMB介导的恶性肿瘤的研究
Binhan Zhao,Yongji Zhu,Ziyang Jin et al.
Binhan Zhao et al.
Background: Pyroptosis, a form of inflammatory programmed cell death, plays a dual role in tumor progression and anti-tumor immunity. Its comprehensive clinical and biological significance in intrahepatic cholangiocarcino...
CircPTP4A2 (hsa_circ_0007364) facilitates non-small cell lung cancer progression by regulating miR-127-5p/SMC3 [0.03%]
circPTP4A2（hsa_circ_0007364）通过调节miR-127-5p/SMC3促进非小细胞肺癌进展
Yali Feng,Jiang Hong,Changgang Yang et al.
Yali Feng et al.
Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer and accounts for a large proportion of cancer-related deaths worldwide. Despite extensive research progress in recent years, the diagnosis and treatment of lung cancer rem...
Multi-omics analysis of deep brain stimulation associated with brain-gut axis modulation and symptom amelioration in a Parkinson's disease mouse model [0.03%]
与脑肠轴调节和症状改善相关的深度脑刺激的多组学分析（以帕金森病小鼠模型为例）
Ye Song,Changxin Yang,Jie Tu et al.
Ye Song et al.
This study aimed to systematically elucidate the molecular mechanisms underlying PD-associated brain-gut dysfunction through multi-omics analyses and to evaluate the therapeutic potential of combined Deep Brain Stimulation (DBS) and Brain-C...