Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma [0.03%]
KDM4B和KDM5A的双重抑制解体融合阳性横纹肌肉瘤中的PAX3-FOXO1转录程序
Junhong Yuan,Qilei Han,Pengxuan Ren et al.
Junhong Yuan et al.
Background: Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by the oncogenic transcription factor PAX3-FOXO1 and is associated with poor clinical outcome. The histone demethylase KDM4B has been implicated in sustainin...
SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma [0.03%]
去琥珀酰化酶SIRT5调控线粒体代谢的机制研究：通过去琥珀酰化TAMM41促进其泛素连接酶UBR5依赖的降解在肺腺癌中的作用研究
Haoyang Yuan,Wenxuan Hu,Xin Lv et al.
Haoyang Yuan et al.
Mitochondrial metabolic reprogramming is essential for lung adenocarcinoma (LUAD) progression, yet the regulatory mechanisms governing mitochondrial phospholipid synthesis remain poorly understood. TAMM41 is a mitochondrial inner-membrane e...
Myricetin attenuates experimental autoimmune prostatitis and inflammatory and oxidative injury in LPS-induced RWPE-1 cells potentially through modulation of MAPK/STAT3/NF-κB/Nrf2 signaling pathway [0.03%]
芦丁通过调节MAPK/STAT3/NF-κB/Nrf2信号通路潜在地减轻实验性自身免疫前列腺炎和LPS诱导的RWPE-1细胞炎症及氧化损伤
Hang Zhang,Dahong Zhang,Yanping Zhang et al.
Hang Zhang et al.
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological condition marked by ongoing pelvic pain, inflammation, and a reduced quality of life. Increasing evidence indicates that dys...
SETD7-mediated epigenetic regulation of LncRNA XIST promotes trophoblast pyroptosis: a study in preeclampsia mouse and cell models [0.03%]
组蛋白甲基化酶SETD7通过表观遗传学调控LncRNA XIST促进滋养细胞焦亡：子痫前期动物及细胞模型研究
Xiaolan Zhao,Lingling Li,Yujue Wang et al.
Xiaolan Zhao et al.
Background: Pre-eclampsia (PE) is a severe pregnancy-specific hypertensive disorder that poses significant risks to both maternal and fetal health. This study seeks to elucidate the mechanism by which SETD7 regulates trop...
Naringin and hesperidin protect ovarian granulosa cells from cisplatin-induced mitochondrial dysfunction by enhancing bioenergetics and mitophagy [0.03%]
芸香苷和hesperidin通过增强生物能量学和线粒体自噬来保护卵巢颗粒细胞免受顺铂引起的线粒体功能障碍
Jiying Liu,Ekramy M Elmorsy,Ahmed Abdeen et al.
Jiying Liu et al.
Background: Cisplatin (CDDP) is a widely deployed chemotherapeutic medication used to treat various solid tumors, but its clinical utility is limited by dose-dependent ovarian toxicity. Naringin (NG) and hesperidin (HD) a...
Transcutaneous auricular vagus nerve stimulation alleviates chronic heart failure by targeting cathepsin K/p53-mediated ferroptosis [0.03%]
经皮耳迷走神经刺激通过靶向组织蛋白酶K/p53介导的铁死亡缓解慢性心力衰竭
Lulu Zhao,Yanzhou Lu,Yuchi Hu et al.
Lulu Zhao et al.
Background: Heart failure remains a major global health challenge, with ferroptosis implicated in its pathogenesis. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown therapeutic potential for heart failur...
Single-cell analysis reveals that NRG1/3-ERBB4 signaling affects metabolic reprogramming and immune escape in Wilms tumor [0.03%]
单细胞分析揭示NRG1/3-ERBB4信号转导影响先天性肾癌的代谢重编程和免疫逃逸
Zhiqiang Gao,Jie Lin,Huafei Tang et al.
Zhiqiang Gao et al.
Background: Wilms tumor presents a heterogeneous tumor microenvironment. This study aimed to characterize the tumor microenvironment and identify prognostic genes to improve therapeutic strategies. ...
The Wnt/StarD7 axis protects retinal ganglion cells from glutamate excitotoxicity by inhibiting ferroptosis [0.03%]
Wnt/StarD7轴通过抑制铁死亡保护视网膜神经节细胞免受谷氨酸毒性的损害
Liwei Zhang,Wen Chu,Xiaoxiao Feng et al.
Liwei Zhang et al.
Background: Glutamate (Glu) accumulation-induced excitotoxicity is a major cause of retinal ganglion cell (RGC) death in glaucoma, and the role of ferroptosis, a novel form of cell death, is critical in this process. The ...
Decoding the Snail transcriptional network: its role in cancer progression and therapy [0.03%]
解码Snail转录网络：其在癌症进展和治疗中的作用
S E Parfenyev,A N Nazarov,A A Daks et al.
S E Parfenyev et al.
The transcription factor Snail is a central regulatory hub that governs the transition from localized tumorigenesis to invasive, metastatic, therapy-resistant disease. Elucidating the mechanisms of Snail-driven epithelial-mesenchymal transi...
NPC2 deficiency as a potential target drives malignancy and chemo-resistance in DLBCL [0.03%]
NPC2缺失通过调节外泌体分泌促进弥漫性大B细胞淋巴瘤恶性进展及耐药性
Yining Yuan,Qiqi Wu,Xinyu Li et al.
Yining Yuan et al.
Background: Diffuse large B-cell lymphoma (DLBCL) remains challenging to treat, with a considerable proportion of patients exhibiting chemo-resistance and poor prognosis. A deeper understanding of the molecular mechanisms...