DNA methylation patterns re-establish during clonal expansion restoring cell-to-cell epialleles heterogeneity [0.03%]
克隆扩增过程中DNA甲基化模式得以重新建立并恢复细胞间表等位基因异质性
Davide Costabile,Maddalena Russo,Rosa Della Monica et al.
Davide Costabile et al.
It is still debated whether the combination of methylated and unmethylated CpGs, defined as epialleles, is stably propagated during cell division or whether epiallele diversity can dynamically emerge over time. By analyzing epiallele profil...
Deep learning-driven decoding of ubiquitination: from regulatory mechanisms to targeted protein degradation [0.03%]
深度学习驱动的泛素化解码：从调控机制到靶向蛋白降解
Jiaqi Zhang,Boyu Xia,Zhe Wang et al.
Jiaqi Zhang et al.
Background: Ubiquitination is a highly dynamic post-translational modification that plays central roles in protein homeostasis, signal transduction, immune regulation, and cell fate control. Through the coordinated action...
Pyrroloquinoline quinone protects heat-stressed porcine oocytes and improves early embryonic development via maintaining mitochondrial integrity and redox homeostasis [0.03%]
吡咯喹啉醌通过维持线粒体完整性和氧化还原稳态来保护热应激下的猪卵母细胞并改善早期胚胎发育
Mianqun Zhang,Qimei Xu,Bo Jia et al.
Mianqun Zhang et al.
Heat stress (HS) is a major environmental factor that impairs female fertility by disrupting oocyte quality and developmental competence. Pyrroloquinoline quinone (PQQ), a redox cofactor with strong antioxidant and mitochondrial-protective ...
Restriction-modification systems and prophages drive genomic diversification in Priestia megaterium [0.03%]
限制修饰系统和前噬菌体驱动Priestia megaterium基因组多样化
Miao Wang,Chuyang Shao,Juan Ignacio Vílchez et al.
Miao Wang et al.
Bacteria are frequently stressed by bacteriophages. Priestia megaterium is a bacterium of both agricultural and biotechnological importance, yet it has been unclear how the interplay between phage-imposed stress and bacterial immunity shape...
Inhibiting the Hif-1α-Drp1 axis alleviates mitochondrial dysfunction and reduces senescence-like changes in myocardial tissue after acute myocardial infarction [0.03%]
缺血性心肌损伤后抑制HIF-1α-Drp1轴缓解线粒体功能障碍及减少类似衰老的变化
Peng Yang,Yiheng Yang,Xiao Huang et al.
Peng Yang et al.
Background: Cellular senescence is a significant pathological process in acute myocardial infarction (AMI), yet its upstream regulatory mechanisms remain unclear. This study reveals that the HIF-1α /Drp1 signaling axis s...
Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis [0.03%]
单细胞转录组分析解锁不同预后脓毒症的异质性和转录调控程序
Yuanming Yang,Yiwei Hua,Suyi Yang et al.
Yuanming Yang et al.
Sepsis has a high mortality rate, yet the cellular heterogeneity and transcriptional regulatory programs associated with divergent clinical outcomes remain incompletely understood. Here, we integrated two peripheral blood single-cell RNA-se...
A novel TAp63γ-Airn regulatory axis governs early myogenic gene networks [0.03%]
TAp63γ-Airn 新调控轴调控早期肌源性基因网络
Veronica Ciuffoli,Maria Cristina Piro,Alessia Angelin et al.
Veronica Ciuffoli et al.
Skeletal muscle development relies on tightly coordinated transcriptional programs, yet the contribution of long non-coding RNAs (lncRNAs) to myogenesis remains largely unexplored. We previously demonstrated that the transcription factor TA...
Simone Sergio,Alessandro Montella,Mara Mancini et al.
Simone Sergio et al.
Serine has recently emerged as an important regulator of epidermal cell growth and skin repair, and modulation of serine metabolism through inhibition of Serine Hydroxy-Methyl Transferases (SHMTs) is already known to attenuate the developme...
Lnc00892 enhances cisplatin sensitivity by inducing apoptosis through the BTAF1/MDM2/STAT5B/XIAP axis in bladder cancer cells [0.03%]
长链非编码RNA Lnc00892通过BTAF1/MDM2/STAT5B/XIAP轴诱导细胞凋亡增强膀胱癌细胞对顺铂的敏感性
Yixin Chang,Ning Sun,Yijie Liu et al.
Yixin Chang et al.
Background: Chemotherapy is the primary mode of treatment for patients with advanced bladder cancer. However, because of their non-specificity, chemotherapy drugs induce many notable side effects in patients. Recent studi...
Integrative single-cell and bulk analyses reveal ATF4-associated immune suppression and WNT/β-catenin signaling in osteosarcoma [0.03%]
整合单细胞和批量分析揭示骨肉瘤中的ATF4相关免疫抑制和WNT/β-catenin信号通路
Xiaomin Ding,Feihu Chen,Jin Zhou et al.
Xiaomin Ding et al.
Background: Osteosarcoma (OS) is highly heterogeneous and often exhibits an immunosuppressive tumor microenvironment, contributing to poor outcomes. The cell-type-resolved role of the ATF/CREB stress-response network, par...