A protocol for computational design of mRNA vaccines with high functionality and specificity [0.03%]
一种用于设计功能性和特异性mRNA疫苗的协议
Mennatallah A Ramadan,Habiba M ElGohary,Ahmed Hi Faraag et al.
Mennatallah A Ramadan et al.
The design of effective mRNA vaccines requires rigorous target selection, optimization, and validation to ensure stability, immunogenicity, specificity, and overall efficacy. A standardized protocol is needed to guide the process from gene ...
Autochthonous dengue transmission in Europe: epidemiology, mechanisms, and modelling insights [0.03%]
欧洲本土登革热的传播：流行病学、机制及模型见解
Giulia Campinopoli,Antonino Di Caro,Alessandra D&#x;Alise et al.
Giulia Campinopoli et al.
Background: Dengue is the most rapidly expanding arboviral infection globally, with rising incidence and widening geographic distribution driven by urbanisation, climate change, vector expansion, and global mobility. Alth...
Rosavin alleviates COPD via inhibition of IL-17-enriched NET formation and NF-κB signaling [0.03%]
通过抑制富集IL-17的NET形成和NF-κB信号通路缓解慢性阻塞性肺疾病(COPD)病症的功效的作用机理研究——淫羊藿苷类成分作用机制的新见解
Guanhua Xiao,Jing Li,Lu Yuan et al.
Guanhua Xiao et al.
Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and is characterized by persistent inflammation, microbiota dysbiosis, and excessive neutrophil extracellular trap (NE...
β3-adrenergic blockade targets fatty acid oxidation to induce ferroptotic vulnerability in pediatric T-ALL [0.03%]
β3肾上腺素受体阻断通过靶向脂肪酸氧化诱导儿童T细胞急性淋巴细胞白血病的铁死亡敏感性
Cristina Banella,Serena Travaglini,Francesco Carrozzo et al.
Cristina Banella et al.
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of childhood ALL. It is associated with a high risk of relapse, with ~25% of patients failing conventional therapy. Resistance is driven by pro-survival si...
FOXK1: a multifaceted regulator in metabolic reprogramming and disease progression [0.03%]
FOXK1代谢重塑和疾病发展的多面调节者
Tingting He,Guangzhi Ma,Gang Yuan
Tingting He
Forkhead box K1 (FOXK1) is an important member of the FOX transcription factor family and functions as a signal-responsive regulator of cellular metabolism, proliferation, differentiation, and stress adaptation. FOXK1 activity is tightly co...
From bone to beyond: osteoclasts dictate metastatic fate in lung adenocarcinoma via the OLFML3-DPPA2 stemness switch [0.03%]
从骨到更远：破骨细胞通过OLFML3-DPPA2干细胞开关决定肺腺癌的转移命运
Rong Qiu,Yang Xue,Yan Deng et al.
Rong Qiu et al.
The unfavorable prognosis of patients with bone metastasis of lung adenocarcinoma (LUAD) is largely due to both osteolytic destruction and tumor stem cell-mediated secondary metastasis. However, the mechanisms by which the bone microenviron...
Multi-omics reveals fibroblast subtypes with distinct roles in inflammatory bowel disease [0.03%]
多组学揭示了在炎症性肠病中具有不同作用的成纤维细胞亚型
Xushun Guo,Mudan Zhang,Jing Han et al.
Xushun Guo et al.
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving complex interactions among epithelial, immune, and stromal components. Fibroblasts are key regulators...
Piceatannol attenuates thoracic aortic aneurysm progression by targeting STK33 [0.03%]
白杨茋通过靶向STK33抑制胸主动脉瘤进展
Yubo Liu,Jie Liu,Ruizheng Shi et al.
Yubo Liu et al.
Background: Thoracic aortic aneurysm (TAA) is a life-threatening vascular condition with limitedpharmacological interventions. This study aimed to identify novel causaldruggable genes and therapeutic candidates for TAA. ...
Comprehensive multi-omics pan-cancer analysis revealed that ANTXR1 is a potential biomarker for diagnosis and immunotherapy [0.03%]
全面的多组学泛癌分析揭示ANTXR1是诊断和免疫治疗的潜在生物标志物
Yue Qiu,Zhu Yu,Weikun Lai et al.
Yue Qiu et al.
Background: Anthrax toxin receptor 1 (ANTXR1, TEM8) has been implicated in tumor angiogenesis and progression, yet its pan-cancer immunological role remains incompletely defined. ...
TRIM71 suppresses cervical cancer progression by inhibiting Nectin4-mediated Wnt/β-catenin signaling [0.03%]
TRIM71通过抑制Nectin4介导的Wnt/β-catenin信号通路抑制宫颈癌进展
Tianyu Liu,Jian Chen,Bao Dai et al.
Tianyu Liu et al.
Background: Tripartite motif-containing 71 (TRIM71), an RNA-binding E3 ubiquitin ligase, plays essential roles in malignant progression, but its function in cervical cancer (CC) remains unclear. ...